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Target
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
Ligand
BDBM50157254
Substrate
n/a
Meas. Tech.
ChEMBL_310277 (CHEMBL833108)
EC50
85±n/a nM
Citation
 Wang, GT; Wang, X; Wang, W; Hasvold, LA; Sullivan, G; Hutchins, CW; O'Conner, S; Gentiles, R; Sowin, T; Cohen, J; Gu, WZ; Zhang, H; Rosenberg, SH; Sham, HL Design and synthesis of o-trifluoromethylbiphenyl substituted 2-amino-nicotinonitriles as inhibitors of farnesyltransferase. Bioorg Med Chem Lett 15:153-8 (2004) [PubMed]  Article 
Target
Name:
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
Synonyms:
Protein farnesyltransferase | Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of EBI is 38702
Components:
This complex has 2 components.
Component 1
Name:
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Synonyms:
CAAX farnesyltransferase subunit alpha | FNTA_MOUSE | FTase-alpha | Fnta | GGTase-I-alpha | Geranylgeranyl transferase type 1 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | Ras proteins prenyltransferase subunit alpha | Type I protein geranyl-geranyltransferase subunit alpha
Type:
PROTEIN
Mol. Mass.:
43994.09
Organism:
Mus musculus
Description:
EBI_10570
Residue:
377
Sequence:
MAATEGVGESAAGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPNPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYITAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILSQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDVYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHCRESDIPASV
  
Component 2
Name:
Protein farnesyltransferase subunit beta
Synonyms:
FNTB_MOUSE | Fntb | Protein farnesyltransferase
Type:
PROTEIN
Mol. Mass.:
48811.61
Organism:
Mus musculus
Description:
EBI_12341
Residue:
437
Sequence:
MASSSSFTYYCPPSSSPVWSEPLYSLRPEHVRERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLILQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDMVMGVPENVLQPTHPVYNIGPEKVIQATTHFLQKPVPGFEECEDEVTSDPATD
  
Inhibitor
Name:
BDBM50157254
Synonyms:
5-[(4-Cyano-benzyloxy)-(3-methyl-3H-imidazol-4-yl)-methyl]-2''-trifluoromethyl-biphenyl-2-carbonitrile | CHEMBL360525
Type:
Small organic molecule
Emp. Form.:
C27H19F3N4O
Mol. Mass.:
472.4612
SMILES:
Cn1cncc1C(OCc1ccc(cc1)C#N)c1ccc(C#N)c(c1)-c1ccccc1C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: