BDBM50157879 CHEMBL1614712
SMILES [H][C@]1(CN2CCC2)C[C@]([H])(C1)n1cc(-c2cccc(OCc3ccccc3)c2)c2c(N)ncnc12
InChI Key InChIKey=AECDBHGVIIRMOI-GRGXKFILSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 70 hits for monomerid = 50157879
TargetTyrosine-protein kinase CSK(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CSK (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 4(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of FGFR4 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase SYK(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of SYK (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibition of EGFR (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: >9.10E+3nMAssay Description:Inhibition of PI3Kalpha (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase receptor UFO(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of AXL (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 130nMAssay Description:Displacement of [3H]-dofetilide from human ERG channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 61nMAssay Description:Inhibition of IGF-1 receptor (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of EphB4 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 1(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MAPK1 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of ACVR1 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of full length IGF-1 receptor (unknown origin) transfected in Ba/F3 cells assessed as cell proliferationMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of GSK3B (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 3(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of FGFR3 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase Lyn(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of LYN (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 7.10E+3nMAssay Description:Inhibition of KDR (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 65nMAssay Description:Inhibition of full length IGF-1 receptor (unknown origin) autophosphorylation transfected in HEK293 cells pretreated for 60 mins followed by IGF-1 st...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CDK2A (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
TargetMAP kinase-activated protein kinase 5(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MAPKAPK5 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of AURKA (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of HER2 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-4(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of ERBB4 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of FGFR1 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase Lck(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 5.60E+3nMAssay Description:Inhibition of LCK (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MAPK14 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: >9.10E+3nMAssay Description:Inhibition of PI3Kdelta (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of FLT3-D835Y mutant (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 800nMAssay Description:Inhibition of PDGFRalpha-V561D mutant (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CDK4D1 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of TYK2 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 892nMAssay Description:Inhibition of full length insulin receptor (unknown origin) autophosphorylation transfected in HEK293 cells pretreated for 60 mins followed by IGF-1 ...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK3(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of JAK3 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of cMET (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
Target3-phosphoinositide-dependent protein kinase 1(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 8.90E+3nMAssay Description:Inhibition of PDK1 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 1.02E+3nMAssay Description:Inhibition of insulin receptor (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: >5.50E+3nMAssay Description:Inhibition of ALK (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of JAK2 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PRKACA (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of RET (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of AKT1 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK1(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of JAK1 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of PI3Kgamma (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Tested for functional activity against neuronal nicotinic acetylcholine receptor(nAChR) expressed in K177 cells using isotopic rubidium efflux assay.More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: >9.00E+3nMAssay Description:Inhibition of PI3K-beta (unknown origin)More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: >9.00E+3nMAssay Description:Inhibition of PI3K-alpha (unknown origin)More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 130nMAssay Description:Inhibition of human ERG by dofetilide binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of Ins receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of EphB4 receptor (unknown origin)More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of Ret (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK1(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Jak1 (unknown origin)More data for this Ligand-Target Pair