BDBM50162074 CHEMBL3792684

SMILES CNC(=O)c1cnc2cc(OC)c(OC)cc2c1Nc1ccccc1

InChI Key InChIKey=KLTXCAGJAJFJJW-UHFFFAOYSA-N

Data  2 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50162074   

TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50162074(CHEMBL3792684)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of MTH1 (unknown origin) using 8-oxo-dGTP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50162074(CHEMBL3792684)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of MTH1 (unknown origin) using 8-oxo-dGTP as substrate preincubated for 15 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50162074(CHEMBL3792684)
Affinity DataKd:  0.200nMAssay Description:Binding affinity to recombinant His-tagged MTH1 isoform p18 (M1 to V156 residues) (unknown origin) assessed as dissociation constant by surface plasm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed