BDBM50162816 CHEMBL180570::Medronic acid::Methylene diphsphonate::Phosphonomethyl-phosphonic acid::methylenediphosphonic acid

SMILES OP(O)(=O)CP(O)(O)=O

InChI Key InChIKey=MBKDYNNUVRNNRF-UHFFFAOYSA-N

Data  9 KI  3 IC50

PDB links: 6 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50162816   

TargetType IV secretion-like conjugative transfer relaxase protein TraI(Escherichia coli (strain SMS-3-5 / SECEC))
University Of North Carolina

Curated by ChEMBL
LigandPNGBDBM50162816(CHEMBL180570 | Medronic acid | Methylene diphsphon...)
Affinity DataKi:  3nMAssay Description:Inhibition of Escherichia coli F plasmid TraI relaxase Y16F mutant assessed as oriT ssDNA cleavage by competitive inhibition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFe(3+)-Zn(2+) purple acid phosphatase(Phaseolus vulgaris)
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50162816(CHEMBL180570 | Medronic acid | Methylene diphsphon...)
Affinity DataKi:  1.40E+5nMAssay Description:Inhibition of red kidney beans purple acid phosphataseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 5A, mitochondrial(Homo sapiens (Human))
University Of Montpellier

Curated by ChEMBL
LigandPNGBDBM50162816(CHEMBL180570 | Medronic acid | Methylene diphsphon...)
Affinity DataKi:  7.30E+5nMAssay Description:Binding affinity towards recombinant human mitochondrial carbonic anhydrase VMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
University Of Montpellier

Curated by ChEMBL
LigandPNGBDBM50162816(CHEMBL180570 | Medronic acid | Methylene diphsphon...)
Affinity DataKi:  8.60E+5nMAssay Description:Binding affinity owards recombinant human transmembrane carbonic anhydrase IXMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
University Of Montpellier

Curated by ChEMBL
LigandPNGBDBM50162816(CHEMBL180570 | Medronic acid | Methylene diphsphon...)
Affinity DataKi:  1.25E+6nMAssay Description:Binding affinity towards human cytosolic carbonic anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 4(Homo sapiens (Human))
University Of Montpellier

Curated by ChEMBL
LigandPNGBDBM50162816(CHEMBL180570 | Medronic acid | Methylene diphsphon...)
Affinity DataKi:  5.34E+6nMAssay Description:Binding affinity towards human membrane associated carbonic anhydrase IVMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrnithine transcarbamylase, mitochondrial(Homo sapiens (Human))
Universit£Tstrasse 16

Curated by ChEMBL
LigandPNGBDBM50162816(CHEMBL180570 | Medronic acid | Methylene diphsphon...)
Affinity DataKi:  9.00E+6nMpH: 8.0Assay Description:Binding affinity against ornithine transcarbamoylase (OTC) produced by Streptococcus faecalis The buffer taken for this study is 50 mM Tris.HCl, 0.5 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrnithine transcarbamylase, mitochondrial(Homo sapiens (Human))
Universit£Tstrasse 16

Curated by ChEMBL
LigandPNGBDBM50162816(CHEMBL180570 | Medronic acid | Methylene diphsphon...)
Affinity DataKi: >2.00E+7nMpH: 7.0Assay Description:Binding affinity against ornithine transcarbamoylase (OTC) produced by Streptococcus faecalis The buffer taken for this study is 50 mM Tris.HCl, 0.5 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrnithine transcarbamylase, mitochondrial(Homo sapiens (Human))
Universit£Tstrasse 16

Curated by ChEMBL
LigandPNGBDBM50162816(CHEMBL180570 | Medronic acid | Methylene diphsphon...)
Affinity DataKi: >2.00E+7nMpH: 6.0Assay Description:Binding affinity against ornithine transcarbamoylase (OTC) produced by Streptococcus faecalis The buffer taken for this study is 50 mM maleate, 0.5 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
University Of Montpellier

Curated by ChEMBL
LigandPNGBDBM50162816(CHEMBL180570 | Medronic acid | Methylene diphsphon...)
Affinity DataIC50:  8.60E+5nMAssay Description:Inhibition of human recombinant carbonic anhydrase 9 pretreated for 15 mins by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
University Of Montpellier

Curated by ChEMBL
LigandPNGBDBM50162816(CHEMBL180570 | Medronic acid | Methylene diphsphon...)
Affinity DataIC50:  1.25E+6nMAssay Description:Inhibition of human recombinant carbonic anhydrase 2 pretreated for 15 mins by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50162816(CHEMBL180570 | Medronic acid | Methylene diphsphon...)
Affinity DataIC50:  4.90E+4nMAssay Description:Inhibition of human recombinant MMP-2 pretreated for 30 mins measured 2 to 4 hrs after Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 substrate addition by fluo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed