BDBM50162956 CHEMBL371352::Dimethyl-(11-methyl-3,3a,8,12b-tetrahydro-2H-1-oxa-dibenzo[e,h]azulen-2-ylmethyl)-amine

SMILES CN(C)C[C@H]1CC2[C@H](O1)c1ccccc1Cc1ccccc21

InChI Key InChIKey=ACTVOFFLDWZANE-ZNCRQWOUSA-N

Data  10 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50162956   

TargetHistamine H1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50162956(CHEMBL371352 | Dimethyl-(11-methyl-3,3a,8,12b-tetr...)
Affinity DataKi:  0.430nMAssay Description:Inhibition of [3H]-pyrilamine binding to human Histamine H1 receptor More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50162956(CHEMBL371352 | Dimethyl-(11-methyl-3,3a,8,12b-tetr...)
Affinity DataKi:  0.930nMAssay Description:Inhibition of [3H]-mesulergine binding to human 5-hydroxytryptamine 2C receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50162956(CHEMBL371352 | Dimethyl-(11-methyl-3,3a,8,12b-tetr...)
Affinity DataKi:  2.5nMAssay Description:Inhibition of [125I]-R91150 binding to human 5-hydroxytryptamine 2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransporter(Rattus norvegicus)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50162956(CHEMBL371352 | Dimethyl-(11-methyl-3,3a,8,12b-tetr...)
Affinity DataKi:  7.80nMAssay Description:Inhibition of [3H]-nisoxetine binding to rat Norepinephrine transpoterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50162956(CHEMBL371352 | Dimethyl-(11-methyl-3,3a,8,12b-tetr...)
Affinity DataKi:  13nMAssay Description:Inhibition of [3H]-5-HT binding to human 5-hydroxytryptamine 7 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50162956(CHEMBL371352 | Dimethyl-(11-methyl-3,3a,8,12b-tetr...)
Affinity DataKi:  61nMAssay Description:Inhibition of [3H]-spiperone binding to human Dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50162956(CHEMBL371352 | Dimethyl-(11-methyl-3,3a,8,12b-tetr...)
Affinity DataKi:  63nMAssay Description:Inhibition of [3H]-SCH-23,390 binding to human Dopamine receptor D1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50162956(CHEMBL371352 | Dimethyl-(11-methyl-3,3a,8,12b-tetr...)
Affinity DataKi:  69nMAssay Description:Inhibition of [3H]-rauwolscine binding to Alpha-2C adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50162956(CHEMBL371352 | Dimethyl-(11-methyl-3,3a,8,12b-tetr...)
Affinity DataKi:  84nMAssay Description:Inhibition of [125I]-iodosulpride binding to human Dopamine receptor D3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50162956(CHEMBL371352 | Dimethyl-(11-methyl-3,3a,8,12b-tetr...)
Affinity DataKi:  126nMAssay Description:Inhibition of [3H]-rauwolscine binding to Alpha-2A adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed