BDBM50165465 CHEMBL3797579

SMILES Fc1ccc(cc1)-c1cnc2nnc(n2n1)C(F)(F)c1ccc2ncccc2c1

InChI Key InChIKey=XQEJWZGYFBXKIF-UHFFFAOYSA-N

Data  7 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50165465   

TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Chinese Academy Of Sciences (Cas)

Curated by ChEMBL
LigandPNGBDBM50165465(CHEMBL3797579)
Affinity DataIC50:  0.460nMAssay Description:Inhibition of c-Met in human MKN45 cells assessed as reduction in cell proliferation after 72 hrs by SRB or MTT assayMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Chinese Academy Of Sciences (Cas)

Curated by ChEMBL
LigandPNGBDBM50165465(CHEMBL3797579)
Affinity DataIC50:  0.850nMAssay Description:Inhibition of c-Met in human EBC-1 cells assessed as reduction in cell proliferation after 72 hrs by SRB or MTT assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
Chinese Academy Of Sciences (Cas)

Curated by ChEMBL
LigandPNGBDBM50165465(CHEMBL3797579)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of recombinant c-Mer (unknown origin) using poly (Glu, Tyr) 4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Chinese Academy Of Sciences (Cas)

Curated by ChEMBL
LigandPNGBDBM50165465(CHEMBL3797579)
Affinity DataIC50:  0.240nMAssay Description:Inhibition of recombinant c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Chinese Academy Of Sciences (Cas)

Curated by ChEMBL
LigandPNGBDBM50165465(CHEMBL3797579)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of recombinant AXL (unknown origin) using poly (Glu, Tyr) 4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNucleoprotein TPR(Mus musculus)
Chinese Academy Of Sciences (Cas)

Curated by ChEMBL
LigandPNGBDBM50165465(CHEMBL3797579)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of TPR-MET in mouse BAF3 cells assessed as reduction in cell proliferation after 72 hrs by SRB or MTT assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor TYRO3(Homo sapiens (Human))
Chinese Academy Of Sciences (Cas)

Curated by ChEMBL
LigandPNGBDBM50165465(CHEMBL3797579)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of recombinant TYRO3 (unknown origin) using poly (Glu, Tyr) 4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed