BDBM50165694 CHEMBL3139629

SMILES FC(F)(F)c1ccc(OC2(CCCN(C2)C(=O)c2cnccc2C(F)(F)F)C(=O)N2CCN(CC2)c2ccccn2)cc1

InChI Key InChIKey=FZHNDKMUCLVBSR-GCUBHELVSA-N

Data  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50165694   

TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50165694(CHEMBL3139629)
Affinity DataIC50:  2.30E+3nMAssay Description:Displacement of Ac-Phe-Arg-Dpr(fluorophore)-Ac6c-(6-Br)Trp-Glu-Glu-Leu-NH2 from human N-terminal His6-tagged MDM2 (17 to 125 residues) expressed in E...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50165694(CHEMBL3139629)
Affinity DataKd:  500nMAssay Description:Binding affinity to human MDM2 by temperature dependent fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed