BDBM50168493 CHEMBL3805479

SMILES NC(=O)c1cncc(OCc2cccc(NC(=O)c3ccc(cc3)-c3cccs3)c2)c1

InChI Key InChIKey=FWFXRUBMUFYKGY-UHFFFAOYSA-N

Data  3 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50168493   

TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50168493(CHEMBL3805479)
Affinity DataKi:  140nMAssay Description:Inhibition of full length human recombinant N-terminal His6-tagged SIRT2 expressed in Escherichia coli BL21(DE3) cells using Ac-RHK-K(Ac)-AMC as subs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50168493(CHEMBL3805479)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of human recombinant SIRT1 expressed in Escherichia coli BL21(DE3) cells using Ac-RHK-K(Ac)-AMC as substrate preincubated for 10 mins foll...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50168493(CHEMBL3805479)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of human recombinant SIRT3 expressed in Escherichia coli BL21(DE3) cells using Ac-RHK-K(Ac)-AMC as substrate preincubated for 10 mins foll...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50168493(CHEMBL3805479)
Affinity DataIC50:  26nMAssay Description:Inhibition of recombinant human C-terminal His-tagged SIRT2 (50 to 389 residues) expressed in Escherichia coli using Ac-RHK-K(Ac)-AMC as substrate in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50168493(CHEMBL3805479)
Affinity DataIC50:  6.64E+4nMAssay Description:Inhibition of human SIRT3 (102 to 399 residues) expressed in Escherichia coli using Ac-RHK-K(Ac)-AMC as substrate incubated for 2 hrs by fluorescence...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50168493(CHEMBL3805479)
Affinity DataIC50:  1.06E+5nMAssay Description:Inhibition of recombinant human N-terminal His-tagged SIRT1 (1 to 747 residues) expressed in Escherichia coli using Ac-RHK-K(Ac)-AMC as substrate inc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed