BDBM50172078 LY-2801653::Merestinib
SMILES Cc1ccc(C(=O)Nc2ccc(Oc3cc4cnn(C)c4cc3-c3cn[nH]c3)c(F)c2)c(=O)n1-c1ccc(F)cc1
InChI Key InChIKey=QHADVLVFMKEIIP-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 50172078
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
University Of Edinburgh
Curated by ChEMBL
University Of Edinburgh
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of human full length AXL after 4 hrs followed by stimulation with human recombinant Gas6 for 15 minutes by cell based assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
University Of Edinburgh
Curated by ChEMBL
University Of Edinburgh
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of human full length AXL by scintillation counting method in presence of 33P-gammaATPMore data for this Ligand-Target Pair
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
University Of Arkansas For Medical Sciences
Curated by ChEMBL
University Of Arkansas For Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 1.20nMAssay Description:Inhibition of RON (unknown origin) by FISH assayMore data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Ocean University Of China And Laboratory For Marine Drugs And Bioproducts
Curated by ChEMBL
Ocean University Of China And Laboratory For Marine Drugs And Bioproducts
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of MNK2 (unknown origin)More data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
A*Star
Curated by ChEMBL
A*Star
Curated by ChEMBL
Affinity DataIC50: 130nMAssay Description:Inhibition of MNK1 (unknown origin)More data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Ocean University Of China And Laboratory For Marine Drugs And Bioproducts
Curated by ChEMBL
Ocean University Of China And Laboratory For Marine Drugs And Bioproducts
Curated by ChEMBL
Affinity DataIC50: 109nMAssay Description:Inhibition of MNK2 (unknown origin)More data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
A*Star
Curated by ChEMBL
A*Star
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of MNK1 (unknown origin)More data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
University Of Arkansas For Medical Sciences
Curated by ChEMBL
University Of Arkansas For Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 4.70nMAssay Description:Inhibition of cMET (unknown origin) by FISH assayMore data for this Ligand-Target Pair