BDBM50173540 1-[5-(tert-Butyl-diphenyl-silanyloxymethyl)-2,5-dihydro-furan-2-yl]-1H-pyrimidine-2,4-dione::CHEMBL371690::dUTPase inhibitor, 5

SMILES CC(C)(C)[Si](OCC1OC(C=C1)n1ccc(=O)[nH]c1=O)(c1ccccc1)c1ccccc1

InChI Key InChIKey=IHZUQZWWKIYBME-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50173540   

TargetDeoxyuridine 5'-triphosphate nucleotidohydrolase(Plasmodium falciparum)
Instituto De Parastiologia Y Biomedicina "Lopez-Neyra

LigandPNGBDBM50173540(1-[5-(tert-Butyl-diphenyl-silanyloxymethyl)-2,5-di...)
Affinity DataKi:  1.16E+3nM ΔG°:  -8.09kcal/molepH: 8.0 T: 2°CAssay Description:Nucleotide hydrolysis was monitored by mixing enzyme and substrate with a rapid kinetic accessory (Hi-Tech Scientific) attached to a spectrophotomete...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDeoxyuridine 5'-triphosphate nucleotidohydrolase(Plasmodium falciparum)
Instituto De Parastiologia Y Biomedicina "Lopez-Neyra

LigandPNGBDBM50173540(1-[5-(tert-Butyl-diphenyl-silanyloxymethyl)-2,5-di...)
Affinity DataKi:  1.20E+3nMAssay Description:Inhibitory constant against Plasmodium falciparum deoxyuridine 5'-triphosphate nucleotidohydrolase expressed in Escherichia coli BL21 (DE3) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPutative deoxyuridine triphosphatase(Leishmania major)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50173540(1-[5-(tert-Butyl-diphenyl-silanyloxymethyl)-2,5-di...)
Affinity DataKi:  1.78E+5nMAssay Description:Inhibitory constant against Leishmania major deoxyuridine 5'-triphosphate nucleotidohydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDeoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50173540(1-[5-(tert-Butyl-diphenyl-silanyloxymethyl)-2,5-di...)
Affinity DataKi: >1.00E+6nMAssay Description:Inhibitory constant against human deoxyuridine 5'-triphosphate nucleotidohydrolase expressed in Escherichia coli BL21 (DE3) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDeoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50173540(1-[5-(tert-Butyl-diphenyl-silanyloxymethyl)-2,5-di...)
Affinity DataKi: >1.00E+6nM ΔG°: >-4.09kcal/molepH: 8.0 T: 2°CAssay Description:Nucleotide hydrolysis was monitored by mixing enzyme and substrate with a rapid kinetic accessory (Hi-Tech Scientific) attached to a spectrophotomete...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetdCTP deaminase(Campylobacter jejuni)
Instituto De Parastiologia Y Biomedicina "Lopez-Neyra

LigandPNGBDBM50173540(1-[5-(tert-Butyl-diphenyl-silanyloxymethyl)-2,5-di...)
Affinity DataKi:  1.00E+9nM ΔG°:  0kcal/molepH: 8.0 T: 2°CAssay Description:Nucleotide hydrolysis was monitored by mixing enzyme and substrate with a rapid kinetic accessory (Hi-Tech Scientific) attached to a spectrophotomete...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed