BDBM50177064 3-Benzyl-9-dimethylamino-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one::9-dimethylamino-3-benzyl-3H-5-thia-1,3,6-triazafluoren-4-one::CHEMBL388087::cid_657896

SMILES CN(C)c1ccnc2sc3c(ncn(Cc4ccccc4)c3=O)c12

InChI Key InChIKey=AVJJIBOWEKYOER-UHFFFAOYSA-N

Data  2 KI  4 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50177064   

TargetMetabotropic glutamate receptor 1(RAT)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50177064(3-Benzyl-9-dimethylamino-3H-pyrido[3',2':4,5]thien...)
Affinity DataKi:  87nMAssay Description:Displacement of [3H]R214127 from mGluR1 in rat cerebellum membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50177064(3-Benzyl-9-dimethylamino-3H-pyrido[3',2':4,5]thien...)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H]MPEP from rat cortex mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM50177064(3-Benzyl-9-dimethylamino-3H-pyrido[3',2':4,5]thien...)
Affinity DataEC50:  2.47E+3nMAssay Description:Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute, TSRI Assay ...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetUbiquitin-conjugating enzyme E2 N(Homo sapiens (Human))
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM50177064(3-Benzyl-9-dimethylamino-3H-pyrido[3',2':4,5]thien...)
Affinity DataIC50: >2.00E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego CA...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetMetabotropic glutamate receptor 1(RAT)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50177064(3-Benzyl-9-dimethylamino-3H-pyrido[3',2':4,5]thien...)
Affinity DataIC50:  281nMAssay Description:Inhibition of rat mGluR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50177064(3-Benzyl-9-dimethylamino-3H-pyrido[3',2':4,5]thien...)
Affinity DataIC50: >1.00E+5nMAssay Description:Antagonist activity at human mGluR5 expressed in 1321N1 cells assessed as effect on L-glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM50177064(3-Benzyl-9-dimethylamino-3H-pyrido[3',2':4,5]thien...)
Affinity DataEC50: >9.51E+4nMAssay Description:Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute, TSRI Assay ...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM50177064(3-Benzyl-9-dimethylamino-3H-pyrido[3',2':4,5]thien...)
Affinity DataEC50:  3.37E+3nMAssay Description:Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute, TSRI Assay ...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50177064(3-Benzyl-9-dimethylamino-3H-pyrido[3',2':4,5]thien...)
Affinity DataIC50:  281nMAssay Description:Antagonist activity at human mGluR1 expressed in 1321N1 cells assessed as effect on L-glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed