BDBM50179207 3-fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamine::CHEMBL120077::JNJ-10198409

SMILES COc1cc2Cc3c(Nc4cccc(F)c4)[nH]nc3-c2cc1OC

InChI Key InChIKey=ZDNURMVOKAERHZ-UHFFFAOYSA-N

Data  34 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50179207   

TargetCyclin-dependent kinase 1(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50179207(3-fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Cdk1Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50179207(3-fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]...)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of PDGFRbetaChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50179207(3-fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of HER2Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50179207(3-fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]...)
Affinity DataIC50:  45nMAssay Description:Inhibition of PDGFRalphaChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50179207(3-fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]...)
Affinity DataIC50:  22nMAssay Description:Inhibition of cAblChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50179207(3-fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]...)
Affinity DataIC50:  100nMAssay Description:Inhibition of LckChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50179207(3-fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]...)
Affinity DataIC50:  185nMAssay Description:Inhibition of c-SrcChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fyn(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50179207(3-fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]...)
Affinity DataIC50:  378nMAssay Description:Inhibition of FynChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50179207(3-fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Cdk2Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50179207(3-fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of Cdk4Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50179207(3-fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]...)
Affinity DataIC50:  4.58E+4nMAssay Description:Inhibition of bFGFR1Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50179207(3-fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human EGFR at 10000 nMChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 7(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50179207(3-fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Cdk7Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed