BDBM50180834 CHEMBL3819302
SMILES FC(F)c1nc2ccccc2n1-c1nc(nc(n1)N1CCN(CCOCCOCCOCCONC(=O)c2ccc(F)c(F)c2Nc2ccc(I)cc2F)CC1)N1CCOCC1
InChI Key InChIKey=RXVJKLFGWMBSIF-UHFFFAOYSA-N
Data 7 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 7 hits for monomerid = 50180834
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
The University Of Michigan Medical School
Curated by ChEMBL
The University Of Michigan Medical School
Curated by ChEMBL
Affinity DataIC50: 0.0150nMAssay Description:Inhibition of purified MEK1 (unknown origin) assessed as reduction in phosphorylation of inactive Erk2 incubated for 30 mins by Kinase-Glo luminescen...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
University Of Michigan
Curated by ChEMBL
University Of Michigan
Curated by ChEMBL
Affinity DataIC50: 4.07E+3nMAssay Description:Inhibition of PI3Kbeta (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
University Of Michigan
Curated by ChEMBL
University Of Michigan
Curated by ChEMBL
Affinity DataIC50: 191nMAssay Description:Inhibition of recombinant human full length His-tagged PI3K p110alpha/p85alpha expressed in baculovirus expression system coexpressing PIK3R1 by TR-F...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Bioland Laboratory (Guangzhou Regenerative Medicine And Health - Guangdong Laboratory)
Curated by ChEMBL
Bioland Laboratory (Guangzhou Regenerative Medicine And Health - Guangdong Laboratory)
Curated by ChEMBL
Affinity DataIC50: 182nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
University Of Michigan
Curated by ChEMBL
University Of Michigan
Curated by ChEMBL
Affinity DataIC50: 942nMAssay Description:Inhibition of recombinant human full length His-tagged PI3K p110delta/p85alpha expressed in baculovirus expression system coexpressing PIK3R1 by TR-F...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
University Of Michigan
Curated by ChEMBL
University Of Michigan
Curated by ChEMBL
Affinity DataIC50: 5.80E+3nMAssay Description:Inhibition of recombinant human full length His-tagged PI3K p110gamma expressed in baculovirus expression system by TR-FRET assayMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
The University Of Michigan Medical School
Curated by ChEMBL
The University Of Michigan Medical School
Curated by ChEMBL
Affinity DataIC50: 398nMAssay Description:Inhibition of recombinant human GST-tagged MEK1 expressed in baculovirus infected Sf9 insect cells using inactive ERK2 as substrate preincubated for ...More data for this Ligand-Target Pair