BDBM50184429 16-methoxy-11-methyl-11-aza-tricyclo[12.4.0.03,8]octadeca-1(18),3(8),4,6,14,16-hexaene::3-methoxy-7-methyl-5,6,7,8,9,14-hexahydrodibenzo[d,g]azecine::6-methoxy-11-methyl-11-aza-tricyclo[12.4.0.0.3,8]octadeca-1(18),3(8),4,6,14,16-hexaene::CHEMBL380330

SMILES COc1ccc2Cc3ccccc3CCN(C)CCc2c1

InChI Key InChIKey=ATCJEKKXEJVYOB-UHFFFAOYSA-N

Data  18 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 50184429   

TargetD(2) dopamine receptor(Homo sapiens (Human))
Friedrich-Schiller-UniversitäT Jena

Curated by ChEMBL
LigandPNGBDBM50184429(16-methoxy-11-methyl-11-aza-tricyclo[12.4.0.03,8]o...)
Affinity DataKi:  0.550nMAssay Description:Inhibition of D2L dopamine receptor in HEK 293 cells by intracellular calcium assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1B) dopamine receptor(Homo sapiens (Human))
Friedrich-Schiller-UniversitäT Jena

Curated by ChEMBL
LigandPNGBDBM50184429(16-methoxy-11-methyl-11-aza-tricyclo[12.4.0.03,8]o...)
Affinity DataKi:  7.20nMAssay Description:Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Friedrich-Schiller-UniversitäT Jena

Curated by ChEMBL
LigandPNGBDBM50184429(16-methoxy-11-methyl-11-aza-tricyclo[12.4.0.03,8]o...)
Affinity DataKi:  12.9nMAssay Description:Displacement of [3H]SCH23390 from human cloned dopamine D2L receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Friedrich-Schiller-UniversitäT Jena

Curated by ChEMBL
LigandPNGBDBM50184429(16-methoxy-11-methyl-11-aza-tricyclo[12.4.0.03,8]o...)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]spiperone from human dopamine D2L receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Friedrich-Schiller-UniversitäT Jena

Curated by ChEMBL
LigandPNGBDBM50184429(16-methoxy-11-methyl-11-aza-tricyclo[12.4.0.03,8]o...)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]spiperone from D2L dopamine receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Friedrich-Schiller-UniversitäT Jena

Curated by ChEMBL
LigandPNGBDBM50184429(16-methoxy-11-methyl-11-aza-tricyclo[12.4.0.03,8]o...)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]spiperone from human cloned dopamine D2L receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Friedrich-Schiller-Universit£T Jena

Curated by ChEMBL
LigandPNGBDBM50184429(16-methoxy-11-methyl-11-aza-tricyclo[12.4.0.03,8]o...)
Affinity DataKi:  22.9nMAssay Description:Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Friedrich-Schiller-Universit£T Jena

Curated by ChEMBL
LigandPNGBDBM50184429(16-methoxy-11-methyl-11-aza-tricyclo[12.4.0.03,8]o...)
Affinity DataKi:  24.1nMAssay Description:Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Friedrich-Schiller-Universit£T Jena

Curated by ChEMBL
LigandPNGBDBM50184429(16-methoxy-11-methyl-11-aza-tricyclo[12.4.0.03,8]o...)
Affinity DataKi:  28.5nMAssay Description:Displacement of [3H]SCH 23390 from D1 dopamine receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Friedrich-Schiller-Universit£T Jena

Curated by ChEMBL
LigandPNGBDBM50184429(16-methoxy-11-methyl-11-aza-tricyclo[12.4.0.03,8]o...)
Affinity DataKi:  28.5nMAssay Description:Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Friedrich-Schiller-Universit£T Jena

Curated by ChEMBL
LigandPNGBDBM50184429(16-methoxy-11-methyl-11-aza-tricyclo[12.4.0.03,8]o...)
Affinity DataKi:  28.5nMAssay Description:Displacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1B) dopamine receptor(Homo sapiens (Human))
Friedrich-Schiller-UniversitäT Jena

Curated by ChEMBL
LigandPNGBDBM50184429(16-methoxy-11-methyl-11-aza-tricyclo[12.4.0.03,8]o...)
Affinity DataKi:  38.3nMAssay Description:Binding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Friedrich-Schiller-Universit£T Jena

Curated by ChEMBL
LigandPNGBDBM50184429(16-methoxy-11-methyl-11-aza-tricyclo[12.4.0.03,8]o...)
Affinity DataKi:  43.4nMAssay Description:Displacement of [3H]spiperone from human dopamine D4 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1B) dopamine receptor(Homo sapiens (Human))
Friedrich-Schiller-UniversitäT Jena

Curated by ChEMBL
LigandPNGBDBM50184429(16-methoxy-11-methyl-11-aza-tricyclo[12.4.0.03,8]o...)
Affinity DataKi:  54nMAssay Description:Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1B) dopamine receptor(Homo sapiens (Human))
Friedrich-Schiller-UniversitäT Jena

Curated by ChEMBL
LigandPNGBDBM50184429(16-methoxy-11-methyl-11-aza-tricyclo[12.4.0.03,8]o...)
Affinity DataKi:  54nMAssay Description:Displacement of [3H]SCH 23390 from human dopamine D5 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Friedrich-Schiller-UniversitäT Jena

Curated by ChEMBL
LigandPNGBDBM50184429(16-methoxy-11-methyl-11-aza-tricyclo[12.4.0.03,8]o...)
Affinity DataKi:  75.7nMAssay Description:Binding affinity to human cloned dopamine D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Friedrich-Schiller-UniversitäT Jena

Curated by ChEMBL
LigandPNGBDBM50184429(16-methoxy-11-methyl-11-aza-tricyclo[12.4.0.03,8]o...)
Affinity DataKi:  75.7nMAssay Description:Binding affinity to D3 dopamine receptor by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Friedrich-Schiller-UniversitäT Jena

Curated by ChEMBL
LigandPNGBDBM50184429(16-methoxy-11-methyl-11-aza-tricyclo[12.4.0.03,8]o...)
Affinity DataKi:  75.7nMAssay Description:Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Friedrich-Schiller-Universit£T Jena

Curated by ChEMBL
LigandPNGBDBM50184429(16-methoxy-11-methyl-11-aza-tricyclo[12.4.0.03,8]o...)
Affinity DataIC50: >1.00E+7nMAssay Description:Inhibition of Electric eel AChE after 2 mins by colorimetric Ellman assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Equus caballus (Horse))
Friedrich-Schiller-Universit£T Jena

Curated by ChEMBL
LigandPNGBDBM50184429(16-methoxy-11-methyl-11-aza-tricyclo[12.4.0.03,8]o...)
Affinity DataIC50: >1.00E+7nMAssay Description:Inhibition of Equine serum BChE after 2 mins by colorimetric Ellman assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed