BDBM50184480 CHEMBL202730::dimethyl-{3-[6-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)-benzoimidazol-1-yl]-propyl}-amine

SMILES CN(C)CCCn1cnc2ccc(cc12)-c1c2CCCn2nc1-c1ccccn1

InChI Key InChIKey=ACNITJMLOMTVSK-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50184480   

TargetMitogen-activated protein kinase kinase kinase 20(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50184480(CHEMBL202730 | dimethyl-{3-[6-(2-pyridin-2-yl-5,6-...)
Affinity DataIC50:  1.59E+4nMAssay Description:Inhibition of MLK7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-2(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50184480(CHEMBL202730 | dimethyl-{3-[6-(2-pyridin-2-yl-5,6-...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of recombinant human TGFbeta R2 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50184480(CHEMBL202730 | dimethyl-{3-[6-(2-pyridin-2-yl-5,6-...)
Affinity DataIC50:  104nMAssay Description:Inhibition of TGFbeta R1 induced transcriptional activation of p3TP-Lux in mink Mv1Lu lung cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50184480(CHEMBL202730 | dimethyl-{3-[6-(2-pyridin-2-yl-5,6-...)
Affinity DataIC50:  398nMAssay Description:Inhibition of recombinant human TGFbeta R1 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed