BDBM50186460 CHEMBL209148::N-(5-(5-(1-acetylpiperazine-4-carbonyl)-4-methoxy-2-methylphenylthio)thiazol-2-yl)-4-((3,3-dimethylbutan-2-ylamino)methyl)benzamide

SMILES COc1cc(C)c(Sc2cnc(NC(=O)c3ccc(CNC(C)C(C)(C)C)cc3)s2)cc1C(=O)N1CCN(CC1)C(C)=O

InChI Key InChIKey=ZHXNIYGJAOPMSO-UHFFFAOYSA-N

Data  1 KI  18 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 50186460   

TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
University Of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50186460(CHEMBL209148 | N-(5-(5-(1-acetylpiperazine-4-carbo...)
Affinity DataKi:  16nMAssay Description:Inhibition of ITKMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
University Of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50186460(CHEMBL209148 | N-(5-(5-(1-acetylpiperazine-4-carbo...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human ITK using poly-Glu-Tyr (4:1) as substrate incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
TargetO94806/P05129/P05771/P17252/P24723/P41743/Q02156/Q04759/Q05513/Q05655/Q15139(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50186460(CHEMBL209148 | N-(5-(5-(1-acetylpiperazine-4-carbo...)
Affinity DataIC50:  2.40E+4nMAssay Description:Inhibition of PKCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50186460(CHEMBL209148 | N-(5-(5-(1-acetylpiperazine-4-carbo...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of SykMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50186460(CHEMBL209148 | N-(5-(5-(1-acetylpiperazine-4-carbo...)
Affinity DataIC50:  2.90E+4nMAssay Description:Inhibition of Cdk2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50186460(CHEMBL209148 | N-(5-(5-(1-acetylpiperazine-4-carbo...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of IKK-betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50186460(CHEMBL209148 | N-(5-(5-(1-acetylpiperazine-4-carbo...)
Affinity DataIC50:  4.10E+3nMAssay Description:Inhibition of BtkMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50186460(CHEMBL209148 | N-(5-(5-(1-acetylpiperazine-4-carbo...)
Affinity DataIC50:  3.60E+4nMAssay Description:Inhibition of GSK3-betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50186460(CHEMBL209148 | N-(5-(5-(1-acetylpiperazine-4-carbo...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of Akt1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fyn(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50186460(CHEMBL209148 | N-(5-(5-(1-acetylpiperazine-4-carbo...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of FynMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 3(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50186460(CHEMBL209148 | N-(5-(5-(1-acetylpiperazine-4-carbo...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of ERK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
University Of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50186460(CHEMBL209148 | N-(5-(5-(1-acetylpiperazine-4-carbo...)
Affinity DataIC50:  19nMAssay Description:Inhibition of ItkMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50186460(CHEMBL209148 | N-(5-(5-(1-acetylpiperazine-4-carbo...)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase TXK(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50186460(CHEMBL209148 | N-(5-(5-(1-acetylpiperazine-4-carbo...)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of TxkMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Tec(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50186460(CHEMBL209148 | N-(5-(5-(1-acetylpiperazine-4-carbo...)
Affinity DataIC50:  1.70E+4nMAssay Description:Inhibition of TecMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50186460(CHEMBL209148 | N-(5-(5-(1-acetylpiperazine-4-carbo...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50186460(CHEMBL209148 | N-(5-(5-(1-acetylpiperazine-4-carbo...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of ZAP70More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50186460(CHEMBL209148 | N-(5-(5-(1-acetylpiperazine-4-carbo...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of Insulin receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha/beta/gamma(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50186460(CHEMBL209148 | N-(5-(5-(1-acetylpiperazine-4-carbo...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of PKAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed