BDBM50187266 (2R,5S)-1-(2-(1-(hydroxymethyl)cyclopentylamino)acetyl)pyrrolidine-2,5-dicarbonitrile::CHEMBL379522

SMILES OCC1(CCCC1)NCC(=O)N1[C@@H](CC[C@@H]1C#N)C#N

InChI Key InChIKey=VZOVKVCGZDERPK-TXEJJXNPSA-N

Data  11 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50187266   

TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50187266((2R,5S)-1-(2-(1-(hydroxymethyl)cyclopentylamino)ac...)
Affinity DataIC50:  92nMAssay Description:Inhibition of DPP4 in cynomolgus monkey plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50187266((2R,5S)-1-(2-(1-(hydroxymethyl)cyclopentylamino)ac...)
Affinity DataIC50:  109nMAssay Description:Inhibition of DPP4 in beagle dog plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50187266((2R,5S)-1-(2-(1-(hydroxymethyl)cyclopentylamino)ac...)
Affinity DataIC50:  104nMAssay Description:Inhibition of human recombinant DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase FAP(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50187266((2R,5S)-1-(2-(1-(hydroxymethyl)cyclopentylamino)ac...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of FAPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 9(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50187266((2R,5S)-1-(2-(1-(hydroxymethyl)cyclopentylamino)ac...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of DPP9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50187266((2R,5S)-1-(2-(1-(hydroxymethyl)cyclopentylamino)ac...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of DPP3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50187266((2R,5S)-1-(2-(1-(hydroxymethyl)cyclopentylamino)ac...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of DPP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetXaa-Pro aminopeptidase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50187266((2R,5S)-1-(2-(1-(hydroxymethyl)cyclopentylamino)ac...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of APPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 8(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50187266((2R,5S)-1-(2-(1-(hydroxymethyl)cyclopentylamino)ac...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of DPP8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50187266((2R,5S)-1-(2-(1-(hydroxymethyl)cyclopentylamino)ac...)
Affinity DataIC50:  109nMAssay Description:Inhibition of DPP4 in beagle dog plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50187266((2R,5S)-1-(2-(1-(hydroxymethyl)cyclopentylamino)ac...)
Affinity DataIC50:  38nMAssay Description:Inhibition of DPP4 in Sprague-Dawley rat plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed