BDBM50188913 CHEMBL213618::N-((S)-1-amino-3-(2,4-dichlorophenyl)propan-2-yl)-5-(2-(methylamino)pyrimidin-4-yl)thiophene-2-carboxamide::N-[(1S)-2-AMINO-1-(2,4-DICHLOROBENZYL)ETHYL]-5-[2-(METHYLAMINO)PYRIMIDIN-4-YL]THIOPHENE-2-CARBOXAMIDE
SMILES CNc1nccc(n1)-c1ccc(s1)C(=O)N[C@H](CN)Cc1ccc(Cl)cc1Cl
InChI Key InChIKey=HHOVRZGUSBMKKU-ZDUSSCGKSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 16 hits for monomerid = 50188913
Affinity DataIC50: 2.60nMAssay Description:Inhibition of AKT3 in presence of 0.2 uM ATPMore data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha/beta/gamma(Homo sapiens (Human))
Chiron
Curated by ChEMBL
Chiron
Curated by ChEMBL
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Homo sapiens (Human))
Chiron
Curated by ChEMBL
Chiron
Curated by ChEMBL
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of CamK2alphaMore data for this Ligand-Target Pair
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Chiron
Curated by ChEMBL
Chiron
Curated by ChEMBL
Affinity DataEC50: 160nMAssay Description:Activity against AKT-mediated PRAS40 T246P phosphorylation in human DOV13 cell lineMore data for this Ligand-Target Pair
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Chiron
Curated by ChEMBL
Chiron
Curated by ChEMBL
Affinity DataEC50: 370nMAssay Description:Activity against AKT-mediated S6RP S235/236P phosphorylation in human DOV13 cell lineMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of GSK3More data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of MetMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of AKT3 in presence of 0.2 uM ATPMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Chiron
Curated by ChEMBL
Chiron
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of RAF1More data for this Ligand-Target Pair
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Chiron
Curated by ChEMBL
Chiron
Curated by ChEMBL
Affinity DataEC50: 320nMAssay Description:Activity against AKT-mediated GSK3 S9P phosphorylation in human DOV13 cell lineMore data for this Ligand-Target Pair