BDBM50192229 3-Bicyclo[2.2.1]hept-5-en-2-yl-6-chloro-1,1-dioxo-1,2,3,4-tetrahydro-1lambda*6*-benzo[1,2,4]thiadiazine-7-sulfonic acid amide::3-Bicyclo[2.2.1]hept-5-en-2-yl-6-chloro-1,1-dioxo-1,2,3,4-tetrahydro-1lambda*6*-benzo[1,2,4]thiadiazine-7-sulfonic acid amide(Clothiazide)::3-Bicyclo[2.2.1]hept-5-en-2-yl-7-chloro-1,1-dioxo-1,2,3,4-tetrahydro-1lambda*6*-benzo[1,2,4]thiadiazine-6-sulfonic acid amide::6-chloro-3,4-dihydro-3-(5-norbornen-2-yl)-2H-1,2,4-benzothiazidiazine-7-sulfonamide-1,1-dioxide::CHEMBL61593::CYCLOTHIAZIDE

SMILES NS(=O)(=O)c1cc2c(NC(NS2(=O)=O)C2CC3CC2C=C3)cc1Cl

InChI Key InChIKey=BOCUKUHCLICSIY-UHFFFAOYSA-N

Data  11 EC50

PDB links: 18 PDB IDs match this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50192229   

TargetGlutamate receptor 4(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50192229(3-Bicyclo[2.2.1]hept-5-en-2-yl-6-chloro-1,1-dioxo-...)
Affinity DataEC50:  3.80E+3nMAssay Description:Activity against human GLUR4 flip expressed in HEK293 cells assesed as glutamate-stimulated calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50192229(3-Bicyclo[2.2.1]hept-5-en-2-yl-6-chloro-1,1-dioxo-...)
Affinity DataEC50:  7.60E+3nMAssay Description:Agonist activity at human GluA2(Q)i expressed in HEK293 cells assessed as enhancement of glutamate-evoked desensitized current by whole cell patch cl...More data for this Ligand-Target Pair
TargetGlutamate receptor 1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50192229(3-Bicyclo[2.2.1]hept-5-en-2-yl-6-chloro-1,1-dioxo-...)
Affinity DataEC50:  2.00E+3nMAssay Description:Activity at recombinant GluA1 receptor flip isoform expressed in Xenopus oocytes co-expressing gamma2-TARP assessed as effect on 10 uM glutamate-indu...More data for this Ligand-Target Pair
TargetGlutamate receptor 1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50192229(3-Bicyclo[2.2.1]hept-5-en-2-yl-6-chloro-1,1-dioxo-...)
Affinity DataEC50:  1.00E+4nMAssay Description:Activity at recombinant GluA1 receptor flop isoform expressed in Xenopus oocytes co-expressing gamma2-TARP assessed as effect on 10 uM glutamate-indu...More data for this Ligand-Target Pair
TargetGlutamate receptor 1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50192229(3-Bicyclo[2.2.1]hept-5-en-2-yl-6-chloro-1,1-dioxo-...)
Affinity DataEC50:  1.98E+4nMAssay Description:Activity at human recombinant GluA1 receptor flip isoform expressed in HEK293 cells assessed as effect on glutamate-induced calcium flux by Fluo-4/AM...More data for this Ligand-Target Pair
TargetGlutamate receptor 2(Rattus norvegicus)
European Research Centre For Drug Discovery And Development (Natsyndrugs)

Curated by ChEMBL
LigandPNGBDBM50192229(3-Bicyclo[2.2.1]hept-5-en-2-yl-6-chloro-1,1-dioxo-...)
Affinity DataEC50:  7.60E+3nMAssay Description:Agonist activity at rat flip iGluR2(Q) expressed in Xenopus laevis oocytes by whole cell patch-clamp methodMore data for this Ligand-Target Pair
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50192229(3-Bicyclo[2.2.1]hept-5-en-2-yl-6-chloro-1,1-dioxo-...)
Affinity DataEC50: >1.00E+5nMAssay Description:Activity at human recombinant GluA2 receptor flop isoform expressed in HEK293 cells assessed as effect on glutamate-induced calcium flux by Fluo-4/AM...More data for this Ligand-Target Pair
TargetGlutamate receptor 3(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50192229(3-Bicyclo[2.2.1]hept-5-en-2-yl-6-chloro-1,1-dioxo-...)
Affinity DataEC50:  1.37E+4nMAssay Description:Activity at human recombinant GluA3 receptor flip isoform expressed in HEK293 cells assessed as effect on glutamate-induced calcium flux by Fluo-4/AM...More data for this Ligand-Target Pair
TargetGlutamate receptor 1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50192229(3-Bicyclo[2.2.1]hept-5-en-2-yl-6-chloro-1,1-dioxo-...)
Affinity DataEC50:  1.00E+3nMAssay Description:Agonist activity at recombinant GluA1 receptor flip isoform expressed in Xenopus oocytesMore data for this Ligand-Target Pair
TargetGlutamate receptor 4(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50192229(3-Bicyclo[2.2.1]hept-5-en-2-yl-6-chloro-1,1-dioxo-...)
Affinity DataEC50:  3.80E+3nMAssay Description:Tested for potentiation towards human iGluR4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50192229(3-Bicyclo[2.2.1]hept-5-en-2-yl-6-chloro-1,1-dioxo-...)
Affinity DataEC50:  2.24E+3nMAssay Description:Activity at human recombinant GluA2 receptor flip isoform expressed in HEK293 cells assessed as effect on glutamate-induced calcium flux by Fluo-4/AM...More data for this Ligand-Target Pair