BDBM50196789 CHEMBL3892788

SMILES Cl.Cc1nnc(C)n1-c1ccc(O[C@@H]2[C@H](Cc3c2cc(Cl)cc3Cl)N2CC[C@@H](O)C2)c(F)c1

InChI Key InChIKey=MDJADLPQDRFYIJ-SIVZDDAJSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50196789   

TargetSodium/hydrogen exchanger 3(Rattus norvegicus)
Sanofi-Aventis Deutschland

Curated by ChEMBL
LigandPNGBDBM50196789(CHEMBL3892788)
Affinity DataIC50:  10nMAssay Description:Inhibition of rat NHE3 expressed in LAP1 cell assessed as intracellular pH recovery measured for 2 mins by CECF-AM dye based FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/hydrogen exchanger 1(Homo sapiens (Human))
Sanofi-Aventis Deutschland

Curated by ChEMBL
LigandPNGBDBM50196789(CHEMBL3892788)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human NHE1 expressed in LAP1 cell assessed as intracellular pH recovery measured for 2 mins by CECF-AM dye based FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/hydrogen exchanger 5(Homo sapiens (Human))
Sanofi-Aventis Deutschland

Curated by ChEMBL
LigandPNGBDBM50196789(CHEMBL3892788)
Affinity DataIC50:  291nMAssay Description:Inhibition of human NHE5 expressed in LAP1 cell assessed as intracellular pH recovery measured for 2 mins by CECF-AM dye based FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Sanofi-Aventis Deutschland

Curated by ChEMBL
LigandPNGBDBM50196789(CHEMBL3892788)
Affinity DataIC50:  900nMAssay Description:Inhibition of CYP2C9 in pooled human hepatic microsomes using diclofenac substrate in presence of NADPHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/hydrogen exchanger isoform 3(Sus scrofa)
Sanofi-Aventis Deutschland

Curated by ChEMBL
LigandPNGBDBM50196789(CHEMBL3892788)
Affinity DataIC50:  7.80nMAssay Description:Inhibition of pig NHE3 expressed in LAP1 cell assessed as intracellular pH recovery measured for 2 mins by CECF-AM dye based FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/hydrogen exchanger 2(Homo sapiens (Human))
Sanofi-Aventis Deutschland

Curated by ChEMBL
LigandPNGBDBM50196789(CHEMBL3892788)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human NHE2 expressed in LAP1 cell assessed as intracellular pH recovery measured for 2 mins by CECF-AM dye based FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed