BDBM50206979 CHEMBL3951973

SMILES Fc1cncc(c1)-c1nc2cc(F)c(Cl)cn2c1C1CC1

InChI Key InChIKey=FJKYRNYWDMFRNT-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50206979   

TargetCytochrome P450 2C9(Homo sapiens (Human))
Merck Usa

Curated by ChEMBL
LigandPNGBDBM50206979(CHEMBL3951973)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of hepatic CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
Merck Usa

Curated by ChEMBL
LigandPNGBDBM50206979(CHEMBL3951973)
Affinity DataIC50:  760nMAssay Description:Inhibition of human CYP11B1-8C7 expressed in Chinese hamster V79 cells using 11-deoxycortisol as substrate preincubated for 1 hr followed by substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Merck Usa

Curated by ChEMBL
LigandPNGBDBM50206979(CHEMBL3951973)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of hepatic CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Merck Usa

Curated by ChEMBL
LigandPNGBDBM50206979(CHEMBL3951973)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of CYP19 (unknown origin) using MFC as substrate and NADPH as cofactor preincubated for 10 mins with cofactor followed by substrate/enzyme...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Merck Usa

Curated by ChEMBL
LigandPNGBDBM50206979(CHEMBL3951973)
Affinity DataIC50:  7.30nMAssay Description:Inhibition of human CYP11B2-CLE9 expressed in Chinese hamster V79 cells using 11-deoxycorticosterone as substrate preincubated for 1 hr followed by s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Merck Usa

Curated by ChEMBL
LigandPNGBDBM50206979(CHEMBL3951973)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of hepatic CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Merck Usa

Curated by ChEMBL
LigandPNGBDBM50206979(CHEMBL3951973)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human CYP17 expressed in African green monkey COS7 cells using 17-hydroxypregnenolone as substrate preincubated for 1 hr followed by su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed