BDBM50212270 CHEMBL3952214

SMILES CC(C)n1cnnc1-c1cccc(n1)N1Cc2ccccc2C1=O

InChI Key InChIKey=NDBJFFCSTXBTFV-UHFFFAOYSA-N

Data  14 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50212270   

TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50212270(CHEMBL3952214)
Affinity DataIC50:  13nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged ASK1 catalytic domain (654 to 971 residues) expressed in baculovirus infected sf21 cells using ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50212270(CHEMBL3952214)
Affinity DataIC50:  14nMAssay Description:Inhibition of ASK1 (unknown origin)More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50212270(CHEMBL3952214)
Affinity DataIC50:  13nMAssay Description:Inhibition of ASK1 (unknown origin)More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Takeda Research In California

Curated by ChEMBL
LigandPNGBDBM50212270(CHEMBL3952214)
Affinity DataIC50: <2.00E+4nMAssay Description:Inhibition of p38 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Takeda Research In California

Curated by ChEMBL
LigandPNGBDBM50212270(CHEMBL3952214)
Affinity DataIC50: <2.00E+4nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-4(Homo sapiens (Human))
Takeda Research In California

Curated by ChEMBL
LigandPNGBDBM50212270(CHEMBL3952214)
Affinity DataIC50: <2.00E+4nMAssay Description:Inhibition of HER4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5'-AMP-activated protein kinase catalytic subunit alpha-1(Homo sapiens (Human))
Takeda Research In California

Curated by ChEMBL
LigandPNGBDBM50212270(CHEMBL3952214)
Affinity DataIC50:  200nMAssay Description:Inhibition of PRKKA1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Takeda Research In California

Curated by ChEMBL
LigandPNGBDBM50212270(CHEMBL3952214)
Affinity DataIC50:  63nMAssay Description:Inhibition of RET (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Takeda Research In California

Curated by ChEMBL
LigandPNGBDBM50212270(CHEMBL3952214)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Takeda Research In California

Curated by ChEMBL
LigandPNGBDBM50212270(CHEMBL3952214)
Affinity DataIC50:  1.26E+3nMAssay Description:Inhibition of ITK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-4(Homo sapiens (Human))
Takeda Research In California

Curated by ChEMBL
LigandPNGBDBM50212270(CHEMBL3952214)
Affinity DataIC50: <2.00E+4nMAssay Description:Inhibition of ERBB4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-A receptor 3(Homo sapiens (Human))
Takeda Research In California

Curated by ChEMBL
LigandPNGBDBM50212270(CHEMBL3952214)
Affinity DataIC50: <2.00E+4nMAssay Description:Inhibition of EPHA3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Takeda Research In California

Curated by ChEMBL
LigandPNGBDBM50212270(CHEMBL3952214)
Affinity DataIC50:  63nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
Takeda Research In California

Curated by ChEMBL
LigandPNGBDBM50212270(CHEMBL3952214)
Affinity DataIC50:  631nMAssay Description:Inhibition of MER (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed