BDBM50216502 4-(3-hydroxy-phenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester::CHEMBL236789::monastrol::rac-monastrol

SMILES CCOC(=O)C1C(NC(=S)N=C1C)c1cccc(O)c1

InChI Key InChIKey=PSKVISJISBFCKP-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50216502   

TargetKinesin-like protein KIFC1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50216502(4-(3-hydroxy-phenyl)-6-methyl-2-thioxo-1,2,3,4-tet...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of recombinant N-terminal His6-tagged KIFC1 (Q305-K673 aa) (unknown origin) expressed in Escherichia coli BL21 (DE3) by malachite green as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Cnrs-Université

Curated by ChEMBL
LigandPNGBDBM50216502(4-(3-hydroxy-phenyl)-6-methyl-2-thioxo-1,2,3,4-tet...)
Affinity DataIC50:  6.10E+3nMAssay Description:Inhibition of Eg5 ATPase activity expressed in Escherichia coli after 12 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Cnrs-Université

Curated by ChEMBL
LigandPNGBDBM50216502(4-(3-hydroxy-phenyl)-6-methyl-2-thioxo-1,2,3,4-tet...)
Affinity DataIC50:  6.10E+3nMAssay Description:Inhibition of Eg5 ATPase activity expressed in HeLa cells after 12 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Cnrs-Université

Curated by ChEMBL
LigandPNGBDBM50216502(4-(3-hydroxy-phenyl)-6-methyl-2-thioxo-1,2,3,4-tet...)
Affinity DataIC50:  1.23E+4nMAssay Description:Inhibition of microtubule-stimulated Eg5 ATPase activity expressed in Escherichia coli after 12 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Cnrs-Université

Curated by ChEMBL
LigandPNGBDBM50216502(4-(3-hydroxy-phenyl)-6-methyl-2-thioxo-1,2,3,4-tet...)
Affinity DataIC50:  5.47E+3nMAssay Description:Inhibition of human full-length Eg5 ATPase activity expressed in Escherichia coli assessed as release of inorganic phosphate after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Cnrs-Université

Curated by ChEMBL
LigandPNGBDBM50216502(4-(3-hydroxy-phenyl)-6-methyl-2-thioxo-1,2,3,4-tet...)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of recombinant human His-tagged Eg5 (1 to 368 residues) assessed as reduction in ATPase activity by Bradford reagent based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Cnrs-Université

Curated by ChEMBL
LigandPNGBDBM50216502(4-(3-hydroxy-phenyl)-6-methyl-2-thioxo-1,2,3,4-tet...)
Affinity DataIC50:  7.45E+3nMAssay Description:Inhibition of human ATPase activity KSP expressed in Escherichia coli after 30 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Cnrs-Université

Curated by ChEMBL
LigandPNGBDBM50216502(4-(3-hydroxy-phenyl)-6-methyl-2-thioxo-1,2,3,4-tet...)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of HsEg5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Cnrs-Université

Curated by ChEMBL
LigandPNGBDBM50216502(4-(3-hydroxy-phenyl)-6-methyl-2-thioxo-1,2,3,4-tet...)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of Eg5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Cnrs-Université

Curated by ChEMBL
LigandPNGBDBM50216502(4-(3-hydroxy-phenyl)-6-methyl-2-thioxo-1,2,3,4-tet...)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of Eg5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50216502(4-(3-hydroxy-phenyl)-6-methyl-2-thioxo-1,2,3,4-tet...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human purified recombinant aurora-A kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed