BDBM50217558 CHEMBL338684

SMILES COc1ccc(C(=O)N[C@@H]2N=C(c3ccccc3)c3cc(C)cc4CCN(c34)C2=O)c(OC)c1

InChI Key InChIKey=RXRVXQTXAUPJIM-VWLOTQADSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50217558   

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Institut De Recherche Jouveinal-Parke Davis

Curated by ChEMBL
LigandPNGBDBM50217558(CHEMBL338684)
Affinity DataIC50:  960nMAssay Description:Inhibition of phosphodiesterase 4 extracted from human U937 cells by using radioligands [3H]-cAMP or [3H]cGMP.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rattus norvegicus)
Institut De Recherche Jouveinal-Parke Davis

Curated by ChEMBL
LigandPNGBDBM50217558(CHEMBL338684)
Affinity DataIC50: >3.00E+3nMAssay Description:Binding affinity against high affinity rolipram binding site (HARBS) was determined by displacing radioactive [3H]rolipram from brain membrane suspen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
Institut De Recherche Jouveinal-Parke Davis

Curated by ChEMBL
LigandPNGBDBM50217558(CHEMBL338684)
Affinity DataIC50:  7.85E+3nMAssay Description:Inhibition of Phosphodiesterase 3 extracted from dog aorta smooth muscle cells by using radioligands [3H]cAMP or [3H]-cGMP.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed