BDBM50217563 CHEMBL125671
SMILES Cc1cc2CCN3c2c(c1)C(=N[C@@H](NC(=O)c1cc(Cl)c(N)c(Cl)c1)C3=O)c1ccccc1
InChI Key InChIKey=IQZZOLVGBYWFIM-QHCPKHFHSA-N
Data 6 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 50217563
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C/cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Institut De Recherche Jouveinal-Parke Davis
Curated by ChEMBL
Institut De Recherche Jouveinal-Parke Davis
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibitory activity against phosphodiesterase 1/5 (PDE1/5) extracted from guinea pig trachea smooth muscle cells by using radioligands [3H]-cAMP or [...More data for this Ligand-Target Pair
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
Institut De Recherche Jouveinal-Parke Davis
Curated by ChEMBL
Institut De Recherche Jouveinal-Parke Davis
Curated by ChEMBL
Affinity DataIC50: 1.75E+4nMAssay Description:Inhibition of Phosphodiesterase 3 extracted from dog aorta smooth muscle cells by using radioligands [3H]cAMP or [3H]-cGMP.More data for this Ligand-Target Pair
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
Institut De Recherche Jouveinal-Parke Davis
Curated by ChEMBL
Institut De Recherche Jouveinal-Parke Davis
Curated by ChEMBL
Affinity DataIC50: 1.03E+4nMAssay Description:Inhibition of phosphodiesterase 3 (PDE3) isolated from the dog aortaMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 300nMAssay Description:Inhibition of phosphodiesterase type 4 isozyme (PDE4) from the U937 human cell line.More data for this Ligand-Target Pair
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C/cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Institut De Recherche Jouveinal-Parke Davis
Curated by ChEMBL
Institut De Recherche Jouveinal-Parke Davis
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of phosphodiesterase 1/5 isozyme (PDE1/5) mixture isolated from the guinea pig trachea.More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 330nMAssay Description:Inhibition of phosphodiesterase 4 extracted from human U937 cells by using radioligands [3H]-cAMP or [3H]cGMP.More data for this Ligand-Target Pair