BDBM50227989 (6S,7S)-7-hydroxycarbamoyl-6-(4-phenyl-piperidine-1-carbonyl)-5-aza-spiro[2.5]octane-5-carboxylic acid methyl ester::CHEMBL442443

SMILES COC(=O)N1CC2(CC2)C[C@@H]([C@H]1C(=O)N1CCC(CC1)c1ccccc1)C(=O)NO

InChI Key InChIKey=YQLRSUQLXQKLGB-ROUUACIJSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50227989   

LigandPNGBDBM50227989((6S,7S)-7-hydroxycarbamoyl-6-(4-phenyl-piperidine-...)
Affinity DataIC50:  19nMAssay Description:Binding affinity to ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50227989((6S,7S)-7-hydroxycarbamoyl-6-(4-phenyl-piperidine-...)
Affinity DataIC50:  472nMAssay Description:Binding affinity to MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50227989((6S,7S)-7-hydroxycarbamoyl-6-(4-phenyl-piperidine-...)
Affinity DataIC50:  169nMAssay Description:Inhibition of HER2 sheddase in BT474 cells by extracellular domain shedding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed