BDBM50228002 (6S,7S)-6-[4-(3-cyclopropyl-phenyl)-3,6-dihydro-2H-pyridine-1-carbonyl]-5-aza-spiro[2.5]octane-7-carboxylic acid hydroxyamide::CHEMBL403161

SMILES ONC(=O)[C@H]1CC2(CC2)CN[C@@H]1C(=O)N1CCC(=CC1)c1cccc(c1)C1CC1

InChI Key InChIKey=UCFPOZCPIVOGIJ-PMACEKPBSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50228002   

LigandPNGBDBM50228002((6S,7S)-6-[4-(3-cyclopropyl-phenyl)-3,6-dihydro-2H...)
Affinity DataIC50:  162nMAssay Description:Inhibition of HER2 sheddase in BT474 cells by extracellular domain shedding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50228002((6S,7S)-6-[4-(3-cyclopropyl-phenyl)-3,6-dihydro-2H...)
Affinity DataIC50:  24nMAssay Description:Binding affinity to MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50228002((6S,7S)-6-[4-(3-cyclopropyl-phenyl)-3,6-dihydro-2H...)
Affinity DataIC50:  48nMAssay Description:Inhibition of HER2 sheddase in BT474 cells by extracellular domain shedding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed