BDBM50233216 CHEMBL4081807

SMILES Cc1cc(Cl)cc(C)c1C(=O)c1sc2cc(O)ccc2c1Oc1ccc(\C=C\C(O)=O)cc1

InChI Key InChIKey=KDWZGXWBBPBEFR-BJMVGYQFSA-N

Data  1 KI  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50233216   

TargetEstrogen receptor(Homo sapiens (Human))
University Of Illinois College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50233216(CHEMBL4081807)
Affinity DataKi:  0.570nMAssay Description:Displacement of [3H]estradiol from full length recombinant human ESR1 expressed in insect cells by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University Of Illinois College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50233216(CHEMBL4081807)
Affinity DataEC50:  0.0700nMAssay Description:Induction of ERalpha degradation in tamoxifen-sensitive human MCF7:WS8 cells after 24 hrs by CellTag 700 staining based In-cell western assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University Of Illinois College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50233216(CHEMBL4081807)
Affinity DataIC50:  2.40nMAssay Description:Antagonist activity at ERalpha in tamoxifen-sensitive human MCF7:WS8 cells assessed as inhibition of estradiol-induced response after 18 hrs by lucif...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed