BDBM50234965 A-740003::CHEMBL255787::N-(1-(2-cyano-3-(quinolin-5-yl)guanidino)-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide::N-(1-{[(Cyanoimino)(5-quinolinylamino)methyl]amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide
SMILES COc1ccc(CC(=O)NC(N=C(NC#N)Nc2cccc3ncccc23)C(C)(C)C)cc1OC
InChI Key InChIKey=PUHSRMSFDASMAE-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 27 hits for monomerid = 50234965
Affinity DataKi: 59nMAssay Description:Displacement of [3H]-A-804598 from rat P2X7 receptor expressed in HEK293 cell membrane by in vitro binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 130nMAssay Description:Displacement of [3H]-A-804598 from human P2X7 receptor expressed in HEK293 cell membrane by in vitro binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Antagonist activity at human recombinant P2X7 receptor expressed in human 1321N1 cells assessed as inhibition of agonist-induced calcium flux by fluo...More data for this Ligand-Target Pair
Affinity DataIC50: 44nMAssay Description:Antagonist activity at human recombinant P2X7 receptor assessed as inhibition of calcium flux by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Antagonist activity at rat recombinant P2X7 receptor expressed in human 1321N1 cells assessed as inhibition of agonist-induced calcium flux by fluoro...More data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Antagonist activity at rat recombinant P2X7 receptor assessed as inhibition of calcium flux by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: 19.9nMAssay Description:Antagonist activity at rat cloned P2X7 receptor expressed in HEK293 cells assessed as inhibition of calcium flux by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: 39.8nMAssay Description:Antagonist activity at human cloned P2X7 receptor expressed in HEK293 cells assessed as inhibition of calcium flux by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataIC50: 39.8nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced ethidium uptakeMore data for this Ligand-Target Pair
Affinity DataIC50: 19.9nMAssay Description:Activity at rat P2X7 receptor expressed in HEK cells assessed as effect on BzATP-induced ethidium uptakeMore data for this Ligand-Target Pair
Affinity DataIC50: 897nMAssay Description:Antagonist activity at P2X7R in Swiss Webster mouse peritoneal macrophages assessed as inhibition of ATP-induced propidium iodide uptake preincubated...More data for this Ligand-Target Pair
Affinity DataIC50: 109nMAssay Description:Antagonist activity at human P2X7R expressed in HEK293 cells assessed as inhibition of ATP-induced ethidium iodide uptake preincubated for 10 mins fo...More data for this Ligand-Target Pair
Affinity DataIC50: 63nMAssay Description:In vitro thromboxane A2 receptor antagonism through inhibition of U-46619 induced contraction of rat isolated thoracic aortic stripMore data for this Ligand-Target Pair
Affinity DataIC50: 86nMAssay Description:In vitro thromboxane A2 receptor antagonism through inhibition of U-46619 induced platelet aggregation in human whole bloodMore data for this Ligand-Target Pair
Affinity DataIC50: 82nMAssay Description:Evaluated for the antagonistic activity against Serotonin 5-hydroxytryptamine 4 receptor in non-electrically stimulated guinea-pig ileum.More data for this Ligand-Target Pair
Affinity DataIC50: 89nMAssay Description:Tested for inhibitory potency against rat liver microsomal squalene synthaseMore data for this Ligand-Target Pair
Affinity DataIC50: 112nMAssay Description:Tested for inhibitory potency against rat liver microsomal squalene synthaseMore data for this Ligand-Target Pair
Affinity DataIC50: 47nMAssay Description:Antagonist activity at P2X7 receptor in Swiss mouse peritoneal macrophages assessed as inhibition of BzATP-induced current at holding potential of -6...More data for this Ligand-Target Pair
Affinity DataIC50: 90nMAssay Description:Antagonist activity at human P2X7 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 750nMAssay Description:Antagonist activity at human P2X7R expressed in HEK293 cells assessed as inhibition of ATP-induced ethidium iodide uptake preincubated for 5 mins fol...More data for this Ligand-Target Pair
Affinity DataIC50: 81nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced calcium-flux measured after 60 mins by F...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Antagonist activity at rat P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced calcium-flux measured after 60 mins by FLI...More data for this Ligand-Target Pair
Affinity DataIC50: 250nMAssay Description:Antagonist activity at mouse P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced calcium-flux measured after 60 mins by F...More data for this Ligand-Target Pair
Affinity DataIC50: 92nMAssay Description:Antagonist activity at human P2X7R expressed in differentiated human THP-1 cells assessed as reduction in BzATP induced YO-PRO uptake by cells incuba...More data for this Ligand-Target Pair
Affinity DataIC50: 156nMAssay Description:Antagonist activity at human P2X7R expressed in differentiated human THP-1 cells assessed as reduction in BzATP induced IL-1beta release incubated fo...More data for this Ligand-Target Pair
Affinity DataIC50: 92nMAssay Description:Antagonist activity at human recombinant P2X7 receptor expressed in human 1321N1 cells assessed as inhibition of BzATP-induced pore formation flux by...More data for this Ligand-Target Pair
Affinity DataIC50: 156nMAssay Description:Antagonist activity at human recombinant P2X7 receptor expressed in human THP1 cells assessed as inhibition of BzATP-induced IL1beta release by enzym...More data for this Ligand-Target Pair