BDBM50239118 CHEMBL4090811

SMILES Fc1cccc(c1)N1CCC[C@@H]1c1cc(cc2c1oc(cc2=O)N1CCOCC1)C(=O)N1CCOCC1

InChI Key InChIKey=GKDQTHKGRBYZKQ-XMMPIXPASA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50239118   

LigandPNGBDBM50239118(CHEMBL4090811)
Affinity DataIC50:  5.10nMAssay Description:Displacement of [3H]baclofen from Gamma-aminobutyric acid type B receptor of rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50239118(CHEMBL4090811)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of PI3Kbeta in PTEN-deficient human MDA-MB-468 cells assessed as decrease in AKT phosphorylation at Ser473 measured after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50239118(CHEMBL4090811)
Affinity DataIC50:  19nMAssay Description:Inhibition of recombinant human PI3Kalpha using PIP2 as substrate preincubated for 20 mins followed by substrate addition measured after 80 mins in p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50239118(CHEMBL4090811)
Affinity DataIC50:  340nMAssay Description:Inhibition of recombinant human PI3Kgamma using PIP2 as substrate preincubated for 20 mins followed by substrate addition measured after 80 mins in p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50239118(CHEMBL4090811)
Affinity DataIC50:  6.10nMAssay Description:Inhibition of recombinant human PI3Kbeta using PIP2 as substrate preincubated for 20 mins followed by substrate addition measured after 80 mins in pr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed