BDBM50239328 2-(3-((dimethylamino)methyl)phenyl)-4-(4-methyl-1H-indol-5-ylamino)thieno[2,3-b]pyridine-5-carbonitrile::CHEMBL402818

SMILES CN(C)Cc1cccc(c1)-c1cc2c(Nc3ccc4[nH]ccc4c3C)c(cnc2s1)C#N

InChI Key InChIKey=CSCOHEYTBLBQMG-UHFFFAOYSA-N

Data  2 KI  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50239328   

TargetProtein kinase C delta type(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50239328(2-(3-((dimethylamino)methyl)phenyl)-4-(4-methyl-1H...)
Affinity DataKi:  96nMAssay Description:Inhibition of PKCdeltaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C delta type(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50239328(2-(3-((dimethylamino)methyl)phenyl)-4-(4-methyl-1H...)
Affinity DataKi:  96nMAssay Description:Inhibition of PKCdeltaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C eta type(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50239328(2-(3-((dimethylamino)methyl)phenyl)-4-(4-methyl-1H...)
Affinity DataIC50:  62nMAssay Description:Inhibition of PKCetaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C delta type(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50239328(2-(3-((dimethylamino)methyl)phenyl)-4-(4-methyl-1H...)
Affinity DataIC50:  26nMAssay Description:Inhibition of human full length PKCdeltaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50239328(2-(3-((dimethylamino)methyl)phenyl)-4-(4-methyl-1H...)
Affinity DataIC50:  520nMAssay Description:Inhibition of LynMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50239328(2-(3-((dimethylamino)methyl)phenyl)-4-(4-methyl-1H...)
Affinity DataIC50:  7.5nMAssay Description:Inhibition of human full length PKCthetaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50239328(2-(3-((dimethylamino)methyl)phenyl)-4-(4-methyl-1H...)
Affinity DataIC50:  28nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C beta type(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50239328(2-(3-((dimethylamino)methyl)phenyl)-4-(4-methyl-1H...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of PKCbetaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C epsilon type(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50239328(2-(3-((dimethylamino)methyl)phenyl)-4-(4-methyl-1H...)
Affinity DataIC50:  17nMAssay Description:Inhibition of PKCepsilonMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50239328(2-(3-((dimethylamino)methyl)phenyl)-4-(4-methyl-1H...)
Affinity DataIC50:  28nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50239328(2-(3-((dimethylamino)methyl)phenyl)-4-(4-methyl-1H...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50239328(2-(3-((dimethylamino)methyl)phenyl)-4-(4-methyl-1H...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of AKTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Mus musculus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50239328(2-(3-((dimethylamino)methyl)phenyl)-4-(4-methyl-1H...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of mouse PKCtheta in KO cells assessed as blockade of anti CD28-stimulated IL2 productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50239328(2-(3-((dimethylamino)methyl)phenyl)-4-(4-methyl-1H...)
Affinity DataIC50:  7.5nMAssay Description:Inhibition of PKCthetaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50239328(2-(3-((dimethylamino)methyl)phenyl)-4-(4-methyl-1H...)
Affinity DataIC50:  7.5nMAssay Description:Inhibition of PKCthetaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50239328(2-(3-((dimethylamino)methyl)phenyl)-4-(4-methyl-1H...)
Affinity DataIC50:  230nMAssay Description:Inhibition of PKCtheta in wild type T-cell assessed as blockade of anti CD3-stimulated IL2 productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed