BDBM50239913 CHEMBL4102714::US10287286, Example 223

SMILES Cc1c(F)c(ccc1-c1cccc2ncnn12)C#N

InChI Key InChIKey=DYYNCYBQURWPHG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50239913   

TargetProlyl hydroxylase EGLN2(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50239913(CHEMBL4102714 | US10287286, Example 223)
Affinity DataIC50:  52nMAssay Description:Inhibition of full length HIF-PHD1 (unknown origin) expressed in baculovirus infected sf9 cells using DLDLEMLAPYIPMDDDFQL/2-Oxoglutarate as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl hydroxylase EGLN2(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50239913(CHEMBL4102714 | US10287286, Example 223)
Affinity DataIC50:  52nMAssay Description:The IC50 values for the PHD1 enzyme (residues 1-407) were determined by mixing increasing amounts of a compound of the invention with a fixed amount ...More data for this Ligand-Target Pair
In DepthDetails US Patent