BDBM50241259 (2S)-2-((S)-2-(3,5-difluorophenyl)-2-hydroxyacetamido)-N-((7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)propanamide::(S)-2-[(S)-2-(3,5-difluoro-phenyl)-2-hydroxy-acetylamino]-N-((S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)-propionamide::CHEMBL392068::LY-411575
SMILES C[C@H](NC(=O)[C@@H](O)c1cc(F)cc(F)c1)C(=O)N[C@H]1c2ccccc2-c2ccccc2N(C)C1=O
InChI Key InChIKey=ULSSJYNJIZWPSB-CVRXJBIPSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 50241259
Affinity DataEC50: 0.114nMAssay Description:Reduction of human wild type PS1-induced amyloid beta40 level in CHO cells overexpressing human APP751 after 24 hrs by liquid phase electrochemilumin...More data for this Ligand-Target Pair
Affinity DataEC50: 0.135nMAssay Description:Reduction of human wild type PS1-induced amyloid beta42 level in CHO cells overexpressing human APP751 after 24 hrs by liquid phase electrochemilumin...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0820nMAssay Description:Inhibition of gamma secretase in HEK293 cells assessed as reduction in amyloid beta40 level incubated for 4 hrs by electrochemiluminescence detection...More data for this Ligand-Target Pair
Affinity DataIC50: 0.390nMAssay Description:Inhibition of gamma secretase mediated Notch signaling in HEK293 cells after 5 hrs by Western blot analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of gamma secretase in HEK293 cells expressing APP 695 assessed as reduction in amyloid beta levels after 5 hrs by Western blot analysisMore data for this Ligand-Target Pair
TargetSignal peptide peptidase-like 2A(Homo sapiens)
The Genomics Institute of The Novartis Research Foundation
Curated by ChEMBL
The Genomics Institute of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of human SPPL2a expressed in HEK293 cells using GAL4-VP16 fusedTNFalpha (1 to 76)-NTF as substrate after 24 hrs by Bright-Glo luciferase r...More data for this Ligand-Target Pair