BDBM50242613 8-Isothiocyanato-5-methyl-6-oxo-5,6-dihydro-4H-2,5,10b-triaza-benzo[e]azulene-3-carboxylic acid ethyl ester::CHEMBL485829

SMILES CCOC(=O)c1ncn-2c1CN(C)C(=O)c1cc(ccc-21)N=C=S

InChI Key InChIKey=HNQZCUNPKHMCQJ-UHFFFAOYSA-N

Data  1 Kd  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50242613   

TargetGamma-aminobutyric acid receptor subunit alpha-1(Homo sapiens (Human))
University Of Bern

Curated by ChEMBL
LigandPNGBDBM50242613(8-Isothiocyanato-5-methyl-6-oxo-5,6-dihydro-4H-2,5...)
Affinity DataKd:  878nMAssay Description:Displacement of [3H]Ro15-1788 from rat GABAA alpha1beta2gamma2 receptor expressed in HEK293 cells after 1 hr assessed as residual binding by liquid s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1(Homo sapiens (Human))
University Of Bern

Curated by ChEMBL
LigandPNGBDBM50242613(8-Isothiocyanato-5-methyl-6-oxo-5,6-dihydro-4H-2,5...)
Affinity DataEC50:  250nMAssay Description:Activity at rat wild type GABAA alpha1beta2gamma2 receptor expressed in xenopus oocytes assessed as GABA-elicited response by two electrode voltage c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed