BDBM50244299 CHEMBL480501::trans-4-(((4-tert-butylcyclohexyl)(1-methyl-5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)amino)methyl)-N-(1H-tetrazol-5-yl)benzamide

SMILES Cn1c(nc2cc(ccc12)C(F)(F)F)N(Cc1ccc(cc1)C(=O)Nc1nnn[nH]1)[C@H]1CC[C@@H](CC1)C(C)(C)C

InChI Key InChIKey=WSMJMACKNHBKSD-XUTJKUGGSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50244299   

TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50244299(CHEMBL480501 | trans-4-(((4-tert-butylcyclohexyl)(...)
Affinity DataIC50:  62nMAssay Description:Antagonist activity against human GCGR expressed in CHO cells assessed as glucagon-induced cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPro-glucagon(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50244299(CHEMBL480501 | trans-4-(((4-tert-butylcyclohexyl)(...)
Affinity DataIC50:  6.80E+3nMAssay Description:Binding affinity against human GLP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastric inhibitory polypeptide(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50244299(CHEMBL480501 | trans-4-(((4-tert-butylcyclohexyl)(...)
Affinity DataIC50:  6.00E+3nMAssay Description:Binding affinity against human GIPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50244299(CHEMBL480501 | trans-4-(((4-tert-butylcyclohexyl)(...)
Affinity DataIC50:  11nMAssay Description:Displacement of [125I]glucagon from human GCGR expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50244299(CHEMBL480501 | trans-4-(((4-tert-butylcyclohexyl)(...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50244299(CHEMBL480501 | trans-4-(((4-tert-butylcyclohexyl)(...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50244299(CHEMBL480501 | trans-4-(((4-tert-butylcyclohexyl)(...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50244299(CHEMBL480501 | trans-4-(((4-tert-butylcyclohexyl)(...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of hERG potassium channelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed