BDBM50244488 CHEMBL4069790

SMILES Cn1cc(cc(Nc2ccc(cn2)C2CN(C2)C2COC2)c1=O)-c1ccnc(N2CCn3c4CC(C)(C)Cc4cc3C2=O)c1CO

InChI Key InChIKey=PJFOJTLHFUGPAS-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50244488   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50244488(CHEMBL4069790)
Affinity DataKi:  0.430nMAssay Description:Inhibition of human recombinant C-terminal polyhistidine tagged BTK (1 to 659 residues)-mediated synthetic peptide substrate phosphorylation expresse...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50244488(CHEMBL4069790)
Affinity DataIC50:  24nMAssay Description:Inhibition of BTK in human whole blood-derived CD19+ B cells assessed as suppression of anti-IgM stimulated-CD69 expression preincubated for 1 hr fol...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed