BDBM50248038 (R)-3-(4-(2,2-dimethyl-1-(5-methylfuran-2-yl)propylamino)-1,2,5-thiadiazol-3-ylamino)-2-hydroxy-N,N-dimethylbenzamide::CHEMBL455431

SMILES CN(C)C(=O)c1cccc(Nc2nsnc2N[C@@H](c2ccc(C)o2)C(C)(C)C)c1O

InChI Key InChIKey=QPFHUUXBBCZCOF-KRWDZBQOSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50248038   

TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50248038((R)-3-(4-(2,2-dimethyl-1-(5-methylfuran-2-yl)propy...)
Affinity DataKi:  14nMAssay Description:Displacement of IL8 from CXCR1 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50248038((R)-3-(4-(2,2-dimethyl-1-(5-methylfuran-2-yl)propy...)
Affinity DataKi:  91nMAssay Description:Displacement of IL8 from CXCR2 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50248038((R)-3-(4-(2,2-dimethyl-1-(5-methylfuran-2-yl)propy...)
Affinity DataIC50:  143nMAssay Description:Displacement of [125I]CXCL8 from CXCR1 receptor in human PMN assessed as myeloperoxidase releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50248038((R)-3-(4-(2,2-dimethyl-1-(5-methylfuran-2-yl)propy...)
Affinity DataIC50:  21nMAssay Description:Displacement of [125I]CXCL1 from CXCR2 receptor in human PMN assessed as myeloperoxidase releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed