BDBM50248629 CHEMBL4076837::US11471446, Compound DBA-9

SMILES CN1CCN(CC1)C(=O)c1ccc2cc(CCNc3ncnc4ccc(cc34)C#N)ccc2c1

InChI Key InChIKey=VNADJTWHOAMTLY-UHFFFAOYSA-N

Data  4 IC50  3 Kd  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50248629   

TargetCyclin-C(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50248629(CHEMBL4076837 | US11471446, Compound DBA-9)
Affinity DataIC50:  24nMAssay Description:Inhibition of full length N-terminal GST/His6-tagged human CDK8 (M1 to Y463 residues)/N-terminal His6-tagged Cyc C (M1 to S283 residues) expressed in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-C(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50248629(CHEMBL4076837 | US11471446, Compound DBA-9)
Affinity DataIC50:  24nMAssay Description:Inhibition of CDK8/Cyclin-C (unknown origin) in presence of [gamma33P]ATP by radiometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-C/Cyclin-dependent kinase 19(Homo sapiens (Human))
University Of South Australia

Curated by ChEMBL
LigandPNGBDBM50248629(CHEMBL4076837 | US11471446, Compound DBA-9)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of CDK19/Cyclin-C (unknown origin) in presence of [gamma33P]ATP by radiometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 8(Homo sapiens (Human))TBA
LigandPNGBDBM50248629(CHEMBL4076837 | US11471446, Compound DBA-9)
Affinity DataKd:  140nMAssay Description:Inhibition of CDK8 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-C(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50248629(CHEMBL4076837 | US11471446, Compound DBA-9)
Affinity DataIC50:  11nMAssay Description:Inhibition of kinase tracer 236 binding to His tagged recombinant human CDK8/cyclin C incubated for 60 min FRET based LanthaScreen Eu-Kinase binding ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-C(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50248629(CHEMBL4076837 | US11471446, Compound DBA-9)
Affinity DataKd:  2nMAssay Description:Binding affinity to kinase tracer 236 binding to His tagged recombinant human CDK8/cyclinC assessed as dissociation constant by TR FRET based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-C/Cyclin-dependent kinase 19(Homo sapiens (Human))
University Of South Australia

Curated by ChEMBL
LigandPNGBDBM50248629(CHEMBL4076837 | US11471446, Compound DBA-9)
Affinity DataKd:  3nMAssay Description:Binding affinity to recombinant human CDK19/cyclinC assessed as dissociation constant by TR FRET based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 8/19(Homo sapiens (Human))
Lu License

US Patent
LigandPNGBDBM50248629(CHEMBL4076837 | US11471446, Compound DBA-9)
Affinity DataEC50:  50nMAssay Description:The results presented in Example 3 and in particular the KinomeScan indicate that the activity of DBA-7 in our proliferation assay was due to inhibit...More data for this Ligand-Target Pair
In DepthDetails US Patent