BDBM50249356 CHEMBL453217::N-(3,5-dimethylphenyl)-4-(4-methylthiazol-2-yl)pyrimidin-2-amine

SMILES Cc1csc(n1)-c1ccnc(Nc2cc(C)cc(C)c2)n1

InChI Key InChIKey=IUVDZGOUQXJDQC-UHFFFAOYSA-N

Data  4 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50249356   

TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249356(CHEMBL453217 | N-(3,5-dimethylphenyl)-4-(4-methylt...)
Affinity DataKi:  56nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249356(CHEMBL453217 | N-(3,5-dimethylphenyl)-4-(4-methylt...)
Affinity DataKi:  100nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249356(CHEMBL453217 | N-(3,5-dimethylphenyl)-4-(4-methylt...)
Affinity DataKi:  1.03E+3nMAssay Description:Inhibition of ZAP70 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249356(CHEMBL453217 | N-(3,5-dimethylphenyl)-4-(4-methylt...)
Affinity DataKi:  2.03E+3nMAssay Description:Inhibition of SRC (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249356(CHEMBL453217 | N-(3,5-dimethylphenyl)-4-(4-methylt...)
Affinity DataIC50:  56nMAssay Description:Inhibition of recombinant Syk (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249356(CHEMBL453217 | N-(3,5-dimethylphenyl)-4-(4-methylt...)
Affinity DataIC50:  1.55E+3nMAssay Description:Inhibition of SYK (unknown origin)-mediated FCepsilonRI signaling activity by mast cell degranulation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed