BDBM50250860 CHEMBL4062567

SMILES OC(=O)c1cc(F)c2nc(sc2c1)N1C2CCC1CC(C2)OCc1c(onc1-c1ccccc1OC(F)(F)F)C1CC1

InChI Key InChIKey=VYLOOGHLKSNNEK-UHFFFAOYSA-N

Data  6 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50250860   

TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50250860(CHEMBL4062567)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human TGR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Mus musculus)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50250860(CHEMBL4062567)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at mouse TGR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Southern Medical University Biomedical Research Center

Curated by ChEMBL
LigandPNGBDBM50250860(CHEMBL4062567)
Affinity DataEC50:  2.60nMAssay Description:Agonist activity at human FXR expressed in HEK293T cells by luciferase reporter assayMore data for this Ligand-Target Pair
TargetBile acid receptor(Homo sapiens (Human))
Southern Medical University Biomedical Research Center

Curated by ChEMBL
LigandPNGBDBM50250860(CHEMBL4062567)
Affinity DataEC50:  0.200nMAssay Description:Agonist activity at recombinant human GST-tagged FXR ligand binding domain (193 to 472 residues) expressed in baculovirus infected insect cells asses...More data for this Ligand-Target Pair
TargetBile acid receptor(Homo sapiens (Human))
Southern Medical University Biomedical Research Center

Curated by ChEMBL
LigandPNGBDBM50250860(CHEMBL4062567)
Affinity DataEC50:  1.10nMAssay Description:Agonist activity at FXR-LBD (unknown origin) assessed as induction of coactivator SRC-1 peptide recruitment measured by TR-FRET assayMore data for this Ligand-Target Pair
TargetBile acid receptor(Homo sapiens (Human))
Southern Medical University Biomedical Research Center

Curated by ChEMBL
LigandPNGBDBM50250860(CHEMBL4062567)
Affinity DataEC50:  0.260nMAssay Description:Agonist activity at human FXR expressed in HEK293T cells assessed as BSEP promoter driven cellular transcriptional activity after 24 hrs by luciferas...More data for this Ligand-Target Pair