BDBM50250867 CHEMBL4103787

SMILES Cc1cc(cc2sc(nc12)N1C2CCC1CC(C2)OCc1c(onc1-c1ccccc1OC(F)(F)F)C1CC1)C(O)=O

InChI Key InChIKey=WSPLOCBXBHAPIN-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50250867   

TargetBile acid receptor(Homo sapiens (Human))
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50250867(CHEMBL4103787)
Affinity DataEC50:  0.490nMAssay Description:Agonist activity at recombinant human GST-tagged FXR ligand binding domain (193 to 472 residues) expressed in baculovirus infected insect cells asses...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50250867(CHEMBL4103787)
Affinity DataEC50:  0.820nMAssay Description:Agonist activity at human FXR expressed in HEK293T cells assessed as BSEP promoter driven cellular transcriptional activity after 24 hrs by luciferas...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed