BDBM50253098 (1R,2R)-5,5-Dichloro-N-(1-cyanocyclopropyl)-2-[4-[4-(methylsulfonyl)phenyl]-1-(2,2,2-trifluoroethyl)-1H-pyrazol-3-yl]cyclohexanecarboxamide::(1R,2R)-5,5-dichloro-N-(1-cyanocyclopropyl)-2-(4-(4-(methylsulfonyl)phenyl)-1-(2,2,2-trifluoroethyl)-1H-pyrazol-3-yl)cyclohexanecarboxamide::CHEMBL523352::MK-1256

SMILES CS(=O)(=O)c1ccc(cc1)-c1cn(CC(F)(F)F)nc1[C@@H]1CCC(Cl)(Cl)C[C@H]1C(=O)NC1(CC1)C#N

InChI Key InChIKey=DSHIORGRZXPVSN-IAGOWNOFSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50253098   

TargetCathepsin K(Oryctolagus cuniculus (rabbit))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50253098((1R,2R)-5,5-Dichloro-N-(1-cyanocyclopropyl)-2-[4-[...)
Affinity DataIC50:  6.10nMAssay Description:Inhibition of rabbit cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50253098((1R,2R)-5,5-Dichloro-N-(1-cyanocyclopropyl)-2-[4-[...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of human Cathepsin KMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCathepsin K(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50253098((1R,2R)-5,5-Dichloro-N-(1-cyanocyclopropyl)-2-[4-[...)
Affinity DataIC50:  0.620nMAssay Description:Inhibition of humanized rabbit cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed