BDBM50253251 CHEMBL4072637

SMILES CNC(=O)c1nc(-c2nc(-c3cnc4ccccn34)c(C)nc2N)n(C)n1

InChI Key InChIKey=KNRONZUHGXIQLA-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50253251   

LigandPNGBDBM50253251(CHEMBL4072637)
Affinity DataIC50:  6nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50253251(CHEMBL4072637)
Affinity DataIC50:  8.40E+3nMAssay Description:Inhibition of PI3Kbeta in PTEN-deficient human MDA-MB-468 cells assessed as reduction in AKT phosphorylation at Ser473More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50253251(CHEMBL4072637)
Affinity DataIC50:  43nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50253251(CHEMBL4072637)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of human PI4KB (1 to 801 residues) by ADP Glo HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphoinositide 3-kinase regulatory subunit 4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50253251(CHEMBL4072637)
Affinity DataIC50:  1.60E+4nMAssay Description:Inhibition of VPS15 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50253251(CHEMBL4072637)
Affinity DataIC50:  87nMAssay Description:Inhibition of PI3Kbeta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50253251(CHEMBL4072637)
Affinity DataIC50:  2.90E+4nMAssay Description:Inhibition of m-TOR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50253251(CHEMBL4072637)
Affinity DataIC50:  16nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 5-phosphate 4-kinase type-2 alpha(Homo sapiens)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50253251(CHEMBL4072637)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of human PI4K2alpha (1 to 479 residues) by ADP Glo HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 5-phosphate 4-kinase type-2 alpha(Homo sapiens)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50253251(CHEMBL4072637)
Affinity DataIC50:  3.80E+4nMAssay Description:Agonist activity at human delta opioid receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVacuolar protein sorting-associated protein 35(Homo sapiens)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50253251(CHEMBL4072637)
Affinity DataIC50:  1.60E+4nMAssay Description:Inhibition of VPS35 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed