BDBM50257350 CHEMBL1738877

SMILES Cn1c(CNc2cccc(c2)C(=O)NCc2ccccc2C(F)(F)F)nnc1-c1ccncc1

InChI Key InChIKey=WFOVEDJTASPCIR-UHFFFAOYSA-N

Data  19 IC50  1 EC50

PDB links: 2 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 50257350   

TargetRhodopsin kinase GRK1(Human)
Takeda Pharmaceutical

Curated by ChEMBL

LigandBDBM50257350(CHEMBL1738877)Copy SMILESCopy InChI

Affinity DataIC50:  3.10E+3nMAssay Description:Inhibition of recombinant human GST-tagged GRK1 expressed in baculovirus infected fall armyworm Sf9 cells after 60 mins by LanthaScreen eu kinase bin...More data for this Ligand-Target Pair

Target InfoNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidPDBPatents

In DepthDetails ArticlePubMed
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TargetBeta-adrenergic receptor kinase 1(Human)
West China Hospital

Curated by ChEMBL

LigandBDBM50257350(CHEMBL1738877)Copy SMILESCopy InChI

Affinity DataIC50:  30nMAssay Description:Inhibition of GRK2 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidPDBPatents

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
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TargetG protein-coupled receptor kinase 6(Human)
Takeda Pharmaceutical

Curated by ChEMBL

LigandBDBM50257350(CHEMBL1738877)Copy SMILESCopy InChI

Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of recombinant human full length GST-tagged GRK6 expressed in baculovirus using ulight topo2alpha as substrate preincubated for 60 mins fo...More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidPDBPatents

In DepthDetails ArticlePubMed
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TargetRhodopsin kinase GRK7(Human)
Takeda Pharmaceutical

Curated by ChEMBL

LigandBDBM50257350(CHEMBL1738877)Copy SMILESCopy InChI

Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of recombinant human full length GST-tagged GRK7 expressed in baculovirus using ulight topo2alpha as substrate preincubated for 60 mins fo...More data for this Ligand-Target Pair

Target InfoNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidPDBPatents

In DepthDetails ArticlePubMed
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TargetProtein kinase C alpha type(Human)
Takeda Pharmaceutical

Curated by ChEMBL

LigandBDBM50257350(CHEMBL1738877)Copy SMILESCopy InChI

Affinity DataIC50:  8.10E+3nMAssay Description:Inhibition of human PKCalpha active using MBP as substrate after 60 mins in presence of [gamma-32]ATP by scintillation countingMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidPDBPatents

In DepthDetails ArticlePubMed
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TargetBeta-adrenergic receptor kinase 1(Human)
West China Hospital

Curated by ChEMBL

LigandBDBM50257350(CHEMBL1738877)Copy SMILESCopy InChI

Affinity DataIC50:  18nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged GRK2 expressed in baculovirus expression system using ulight topo2alpha as substrate preincubat...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidPDBPatents

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
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TargetRho-associated protein kinase 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL

LigandBDBM50257350(CHEMBL1738877)Copy SMILESCopy InChI

Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged ROCK2 catalytic domain (1 to 553 residues) expressed in baculovirus expression system using STK...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidPDBPatents

In DepthDetails ArticlePubMed
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TargetG protein-coupled receptor kinase 5(Human)
Takeda Pharmaceutical

Curated by ChEMBL

LigandBDBM50257350(CHEMBL1738877)Copy SMILESCopy InChI

Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of recombinant human full length GST-tagged GRK5 expressed in baculovirus using ulight topo2alpha as substrate preincubated for 60 mins fo...More data for this Ligand-Target Pair

Target InfoPDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidPDBPatents

In DepthDetails ArticlePubMed
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TargetRhodopsin kinase GRK1(Bovine)
University of Michigan

Curated by ChEMBL

LigandBDBM50257350(CHEMBL1738877)Copy SMILESCopy InChI

Affinity DataIC50:  5.21E+4nMAssay Description:Inhibitory concentration against alpha-galactosidase of coffee beanMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBPatents

In DepthDetails ArticlePubMed
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TargetBeta-adrenergic receptor kinase 1(Human)
West China Hospital

Curated by ChEMBL

LigandBDBM50257350(CHEMBL1738877)Copy SMILESCopy InChI

Affinity DataIC50:  30nMAssay Description:Inhibition of GRK2 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidPDBPatents

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
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TargetG protein-coupled receptor kinase 5(Bovine)
University of Michigan

Curated by ChEMBL

LigandBDBM50257350(CHEMBL1738877)Copy SMILESCopy InChI

Affinity DataIC50:  9.20E+3nMAssay Description:Binding affinity towards serotonin transporter determined using [3H]paroxetine as radioligandMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBPatents

In DepthDetails ArticlePubMed
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TargetBeta-adrenergic receptor kinase 1(Human)
West China Hospital

Curated by ChEMBL

LigandBDBM50257350(CHEMBL1738877)Copy SMILESCopy InChI

Affinity DataEC50:  1.00E+4nMAssay Description:Inhibition of human GRK2 expressed in HEK-B2 cells assessed as isoproterenol-stimulated cAMP accumulation preincubation for 20 mins followed by isopr...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidPDBPatents

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
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TargetBeta-adrenergic receptor kinase 1(Bovine)
University of Michigan

Curated by ChEMBL

LigandBDBM50257350(CHEMBL1738877)Copy SMILESCopy InChI

Affinity DataIC50:  30nMAssay Description:Inhibition of bovine GRK2 S670A mutant after 5 mins in presence of ATP by phosphorimaging assayMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidPDBPatents

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
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TargetRhodopsin kinase GRK1(Human)
Takeda Pharmaceutical

Curated by ChEMBL

LigandBDBM50257350(CHEMBL1738877)Copy SMILESCopy InChI

Affinity DataIC50:  3.10E+3nMAssay Description:Inhibition of GRK1 (unknown origin)More data for this Ligand-Target Pair

Target InfoNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidPDBPatents

In DepthDetails ArticlePubMed
Copy BDB DOI
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TargetG protein-coupled receptor kinase 5(Human)
Takeda Pharmaceutical

Curated by ChEMBL

LigandBDBM50257350(CHEMBL1738877)Copy SMILESCopy InChI

Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of GRK5 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidPDBPatents

In DepthDetails ArticlePubMed
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TargetG protein-coupled receptor kinase 6(Human)
Takeda Pharmaceutical

Curated by ChEMBL

LigandBDBM50257350(CHEMBL1738877)Copy SMILESCopy InChI

Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of GRK6 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidPDBPatents

In DepthDetails ArticlePubMed
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TargetRhodopsin kinase GRK7(Human)
Takeda Pharmaceutical

Curated by ChEMBL

LigandBDBM50257350(CHEMBL1738877)Copy SMILESCopy InChI

Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of GRK7 (unknown origin)More data for this Ligand-Target Pair

Target InfoNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidPDBPatents

In DepthDetails ArticlePubMed
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TargetO94806/P05129/P05771/P17252/P24723/P41743/Q02156/Q04759/Q05513/Q05655/Q15139(Human)
Hefei University of Technology

Curated by ChEMBL

LigandBDBM50257350(CHEMBL1738877)Copy SMILESCopy InChI

Affinity DataIC50:  8.10E+3nMAssay Description:Inhibition of PKC (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaantibodypediaantibodypediaantibodypediaantibodypediaantibodypediaantibodypediaantibodypediaantibodypediaantibodypediaantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidPDBPatents

In DepthDetails ArticlePubMed
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TargetBeta-adrenergic receptor kinase 2(Human)
Hefei University of Technology

Curated by ChEMBL

LigandBDBM50257350(CHEMBL1738877)Copy SMILESCopy InChI

Affinity DataIC50:  5.40nMAssay Description:Inhibition of GRK3 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
DrugBankantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidPDBPatents

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI
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TargetBeta-adrenergic receptor kinase 2(Human)
Hefei University of Technology

Curated by ChEMBL

LigandBDBM50257350(CHEMBL1738877)Copy SMILESCopy InChI

Affinity DataIC50:  5.40nMAssay Description:Inhibition of recombinant human full length GST-tagged GRK3 expressed in baculovirus using ulight topo2alpha as substrate preincubated for 60 mins fo...More data for this Ligand-Target Pair

Target InfoPDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
DrugBankantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidPDBPatents

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI
Copy reaction URL