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Target
Beta-adrenergic receptor kinase 2
Ligand
BDBM50257350
Substrate
n/a
Meas. Tech.
ChEMBL_2236429 (CHEMBL5150325)
IC50
5.4±n/a nM
Citation
 Xie, Z; Yang, X; Duan, Y; Han, J; Liao, C Small-Molecule Kinase Inhibitors for the Treatment of Nononcologic Diseases. J Med Chem 64:1283-1345 (2021) [PubMed] 
Target
Name:
Beta-adrenergic receptor kinase 2
Synonyms:
ADRBK2 | ARBK2_HUMAN | BARK2 | GRK3
Type:
PROTEIN
Mol. Mass.:
79721.92
Organism:
Homo sapiens (Human)
Description:
ChEMBL_615172
Residue:
688
Sequence:
MADLEAVLADVSYLMAMEKSKATPAARASKRIVLPEPSIRSVMQKYLAERNEITFDKIFNQKIGFLLFKDFCLNEINEAVPQVKFYEEIKEYEKLDNEEDRLCRSRQIYDAYIMKELLSCSHPFSKQAVEHVQSHLSKKQVTSTLFQPYIEEICESLRGDIFQKFMESDKFTRFCQWKNVELNIHLTMNEFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKEMRFYATEIILGLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTVNVELPDTFSPELKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDCDQELYKNFPLVISERWQQEVTETVYEAVNADTDKIEARKRAKNKQLGHEEDYALGKDCIMHGYMLKLGNPFLTQWQRRYFYLFPNRLEWRGEGESRQNLLTMEQILSVEETQIKDKKCILFRIKGGKQFVLQCESDPEFVQWKKELNETFKEAQRLLRRAPKFLNKPRSGTVELPKPSLCHRNSNGL
  
Inhibitor
Name:
BDBM50257350
Synonyms:
CHEMBL1738877
Type:
Small organic molecule
Emp. Form.:
C24H21F3N6O
Mol. Mass.:
466.4583
SMILES:
Cn1c(CNc2cccc(c2)C(=O)NCc2ccccc2C(F)(F)F)nnc1-c1ccncc1
Structure:
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