BDBM50259148 (-)2-({(trans)-2-[(3-isopropyl-7-oxo-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)methyl]cyclohexyl}amino)-4-(trifluoromethyl)pyrimidine-5-carboxylic acid::CHEMBL466280

SMILES CC(C)c1[nH]nc2c1nc(C[C@@H]1CCCC[C@H]1Nc1ncc(C(O)=O)c(n1)C(F)(F)F)[nH]c2=O

InChI Key InChIKey=UJQKNBFBUSXTSO-CMPLNLGQSA-N

Data  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50259148   

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50259148((-)2-({(trans)-2-[(3-isopropyl-7-oxo-6,7-dihydro-1...)
Affinity DataIC50:  370nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50259148((-)2-({(trans)-2-[(3-isopropyl-7-oxo-6,7-dihydro-1...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PDE1aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50259148((-)2-({(trans)-2-[(3-isopropyl-7-oxo-6,7-dihydro-1...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PDE1bMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50259148((-)2-({(trans)-2-[(3-isopropyl-7-oxo-6,7-dihydro-1...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PDE1cMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50259148((-)2-({(trans)-2-[(3-isopropyl-7-oxo-6,7-dihydro-1...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of PDE3aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50259148((-)2-({(trans)-2-[(3-isopropyl-7-oxo-6,7-dihydro-1...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of PDE3bMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50259148((-)2-({(trans)-2-[(3-isopropyl-7-oxo-6,7-dihydro-1...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of PDE8bMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50259148((-)2-({(trans)-2-[(3-isopropyl-7-oxo-6,7-dihydro-1...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of PDE4bMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50259148((-)2-({(trans)-2-[(3-isopropyl-7-oxo-6,7-dihydro-1...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of PDE4cMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50259148((-)2-({(trans)-2-[(3-isopropyl-7-oxo-6,7-dihydro-1...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of PDE4dMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50259148((-)2-({(trans)-2-[(3-isopropyl-7-oxo-6,7-dihydro-1...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of PDE7aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 7B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50259148((-)2-({(trans)-2-[(3-isopropyl-7-oxo-6,7-dihydro-1...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of PDE7bMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50259148((-)2-({(trans)-2-[(3-isopropyl-7-oxo-6,7-dihydro-1...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of PDE8aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50259148((-)2-({(trans)-2-[(3-isopropyl-7-oxo-6,7-dihydro-1...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of PDE4aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed