BDBM50259244 CHEMBL4076393::US10266550, Compound 16
SMILES N[C@H]1CCN(C1)c1c(F)cc2c3c1oc1cc(ccc1n3cc(C(O)=O)c2=O)[N+]([O-])=O
InChI Key InChIKey=MDXFAQWIWGBZRL-VIFPVBQESA-N
Data 5 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 50259244
TargetDNA topoisomerase 1(Escherichia coli (strain K12))
The Florida International University Board of Trustees
US Patent
The Florida International University Board of Trustees
US Patent
Affinity DataIC50: 480nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
TargetDNA gyrase subunit B(Escherichia coli (strain K12))
The Florida International University Board of Trustees
US Patent
The Florida International University Board of Trustees
US Patent
Affinity DataIC50: 3.90E+3nMAssay Description:DNA gyrase supercoiling assays were carried out by mixing the compounds and the enzyme in a similar manner as above (EcTopI relaxation inhibition ass...More data for this Ligand-Target Pair
Affinity DataIC50: 1.95E+3nMAssay Description:Inhibition of human topoisomerase-2alpha assessed as reduction in enzyme-mediated decatenation using kinetoplast DNA as substrate after 15 mins by et...More data for this Ligand-Target Pair
Affinity DataIC50: 2.93E+3nMAssay Description:Human Topoisomerase IIα assays were carried out by adding the compounds to 185 ng of kinetoplast DNA (kDNA, from TopoGen) in the buffer supplied...More data for this Ligand-Target Pair
TargetDNA topoisomerase 1(Homo sapiens (Human))
The Florida International University Board of Trustees
US Patent
The Florida International University Board of Trustees
US Patent
Affinity DataIC50: 7.80E+3nMAssay Description:Human topoisomerase I relaxation assays were carried out with 0.5 U of enzyme in reaction buffer supplied by the manufacturer. The enzyme was mixed w...More data for this Ligand-Target Pair