BDBM50264419 CHEMBL4073553

SMILES O=C(NCCc1nccs1)c1cnc2c(SSc3cccc4cc(cnc34)C(=O)NCCc3nccs3)cccc2c1

InChI Key InChIKey=RNEOHKZPZKEZCQ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50264419   

Target26S proteasome non-ATPase regulatory subunit 14(Homo sapiens (Human))
University Of California San Diego

Curated by ChEMBL
LigandPNGBDBM50264419(CHEMBL4073553)
Affinity DataIC50:  390nMAssay Description:Inhibition of 26S proteasome regulatory subunit RPN11 deubiquitinating activity in human erythrocytes using Ub4-pepOG protein substrate preincubated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSTAM-binding protein(Homo sapiens (Human))
University Of California San Diego

Curated by ChEMBL
LigandPNGBDBM50264419(CHEMBL4073553)
Affinity DataIC50:  4.50E+3nMAssay Description:Inhibition of AMSH (unknown origin) using DiUbK63TAMRA as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCOP9 signalosome complex subunit 5(Homo sapiens (Human))
University Of California San Diego

Curated by ChEMBL
LigandPNGBDBM50264419(CHEMBL4073553)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of CSN5 (unknown origin) using SCFskp2-Nedd8OG as substrate after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target26S proteasome non-ATPase regulatory subunit 14(Homo sapiens (Human))
University Of California San Diego

Curated by ChEMBL
LigandPNGBDBM50264419(CHEMBL4073553)
Affinity DataIC50:  7.74E+4nMAssay Description:Inhibition of 26S proteasome regulatory subunit RPN11 deubiquitinating activity in human erythrocytes using Ub4-pepOG protein substrate preincubated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target26S proteasome non-ATPase regulatory subunit 14(Homo sapiens (Human))
University Of California San Diego

Curated by ChEMBL
LigandPNGBDBM50264419(CHEMBL4073553)
Affinity DataIC50:  600nMAssay Description:Inhibition of 26S proteasome regulatory subunit RPN11 deubiquitinating activity in beta5 inhibitor MG132 pretreated human HeLa cells expressing UbG76...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed