BDBM50267255 4-[(4-Furan-3-yl-3-hydroxy-benzylamino)-methylene]-6-iodo-4Hisoquinoline-1,3-dione::CHEMBL504547

SMILES Oc1cc(CNC=C2C(=O)NC(=O)c3ccc(I)cc23)ccc1-c1ccoc1

InChI Key InChIKey=CUISPPCDYZFGCY-UHFFFAOYSA-N

Data  19 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 50267255   

TargetInsulin receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267255(4-[(4-Furan-3-yl-3-hydroxy-benzylamino)-methylene]...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of IR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267255(4-[(4-Furan-3-yl-3-hydroxy-benzylamino)-methylene]...)
Affinity DataIC50:  1.02E+4nMAssay Description:Inhibition of AKT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267255(4-[(4-Furan-3-yl-3-hydroxy-benzylamino)-methylene]...)
Affinity DataIC50:  2.44E+4nMAssay Description:Inhibition of CDK1/Cyclin B1 (unknown origin) assessed as inhibition of retinoblastoma susceptibility gene product phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267255(4-[(4-Furan-3-yl-3-hydroxy-benzylamino)-methylene]...)
Affinity DataIC50:  60nMAssay Description:Inhibition of CDK4/Cyclin D1 (unknown origin) assessed as inhibition of retinoblastoma susceptibility gene product phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoblastoma-associated protein(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267255(4-[(4-Furan-3-yl-3-hydroxy-benzylamino)-methylene]...)
Affinity DataIC50:  610nMAssay Description:Inhibition of retinoblastoma susceptibility gene product phosphorylation in human MCF7 cells after 24 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267255(4-[(4-Furan-3-yl-3-hydroxy-benzylamino)-methylene]...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of Src (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267255(4-[(4-Furan-3-yl-3-hydroxy-benzylamino)-methylene]...)
Affinity DataIC50:  8.50E+3nMAssay Description:Inhibition of LYN (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267255(4-[(4-Furan-3-yl-3-hydroxy-benzylamino)-methylene]...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267255(4-[(4-Furan-3-yl-3-hydroxy-benzylamino)-methylene]...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of STAT3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267255(4-[(4-Furan-3-yl-3-hydroxy-benzylamino)-methylene]...)
Affinity DataIC50:  2.59E+4nMAssay Description:Inhibition of PKCtheta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267255(4-[(4-Furan-3-yl-3-hydroxy-benzylamino)-methylene]...)
Affinity DataIC50:  1.80E+4nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267255(4-[(4-Furan-3-yl-3-hydroxy-benzylamino)-methylene]...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of LCK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267255(4-[(4-Furan-3-yl-3-hydroxy-benzylamino)-methylene]...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of IKK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267255(4-[(4-Furan-3-yl-3-hydroxy-benzylamino)-methylene]...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Braf (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267255(4-[(4-Furan-3-yl-3-hydroxy-benzylamino)-methylene]...)
Affinity DataIC50: >4.00E+3nMAssay Description:Inhibition of Tpl2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50267255(4-[(4-Furan-3-yl-3-hydroxy-benzylamino)-methylene]...)
Affinity DataIC50:  1.70E+4nMAssay Description:Inhibition of PDK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267255(4-[(4-Furan-3-yl-3-hydroxy-benzylamino)-methylene]...)
Affinity DataIC50:  1.90E+4nMAssay Description:Inhibition of MK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267255(4-[(4-Furan-3-yl-3-hydroxy-benzylamino)-methylene]...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of KDR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267255(4-[(4-Furan-3-yl-3-hydroxy-benzylamino)-methylene]...)
Affinity DataIC50:  4.70E+3nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin) assessed as inhibition of retinoblastoma susceptibility gene product phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed