BDBM50269057 (1S,2S,5S)-N-hydroxy-5-(2-oxo-2-(piperidin-1-yl)ethyl)-2-(4-phenylpiperazine-1-carbonyl)cyclohexanecarboxamide::CHEMBL496628

SMILES ONC(=O)[C@H]1C[C@@H](CC(=O)N2CCCCC2)CC[C@@H]1C(=O)N1CCN(CC1)c1ccccc1

InChI Key InChIKey=SPGSQKKTHWOODB-BVSLBCMMSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50269057   

TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50269057((1S,2S,5S)-N-hydroxy-5-(2-oxo-2-(piperidin-1-yl)et...)
Affinity DataIC50:  683nMAssay Description:Inhibition of human MMP9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50269057((1S,2S,5S)-N-hydroxy-5-(2-oxo-2-(piperidin-1-yl)et...)
Affinity DataIC50:  100nMAssay Description:Inhibition of human MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50269057((1S,2S,5S)-N-hydroxy-5-(2-oxo-2-(piperidin-1-yl)et...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of human MMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50269057((1S,2S,5S)-N-hydroxy-5-(2-oxo-2-(piperidin-1-yl)et...)
Affinity DataIC50:  18nMAssay Description:Inhibition of HER2 extracellular domain sheddase activity in human BT474 cells after 72 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50269057((1S,2S,5S)-N-hydroxy-5-(2-oxo-2-(piperidin-1-yl)et...)
Affinity DataIC50:  15nMAssay Description:Inhibition of human recombinant ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50269057((1S,2S,5S)-N-hydroxy-5-(2-oxo-2-(piperidin-1-yl)et...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of human MMP3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed